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Description:
Excinuclease cho (EC 3.1.25.-) (Endonuclease cho) (UvrC homologprotein).
Molecular weight: 33363
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
16-APR-2002, integrated into UniProtKB/Swiss-Prot.
16-APR-2002, sequence version 2.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Salmonella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein CHO_SALTY:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE008757 | AAL20234.1 | ALT_INIT |
| GenomeReviews | AE006468_GR | STM1309.1 | |
| StyGene | SG????? | cho. | |
| BioCyc | STYP99287:STM1309-MONOMER | -.1 | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| SMART | SM00465 | GIYc | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; Hydrolase; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX MEDLINE=21534948; PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA Waterston R., Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT LT2.";
RL Nature 413:852-856(2001).
Feature:
CHAIN 1 293 Excinuclease cho.
/FTId=PRO_0000138374.
Comments:
-!- FUNCTION: Incises the DNA at the 3' side of a lesion during
nucleotide excision repair. Incises the DNA farther away from the
lesion than uvrC. Not able to incise the 5' site of a lesion. When
a lesion remains because uvrC is not able to induce the 3'
incision, cho incises the DNA. Then uvrC makes the 5' incision.
The combined action of cho and uvrC broadens the substrate range
of nucleotide excision repair (By similarity).
-!- SIMILARITY: Contains 1 uvrC C-terminal domain.
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Sequence length: 293
MVRRQSAPRL EFEAAAIYEY PEHLRPFLSE APALPGVYIF HSESDTLPLY IGKSVNIRSR
VLSHLRTPDE ATMLRQARRI SWICTAGEMG ALLLEARLIK EQQPLFNKRL RRNRQLCSLQ
LSEQKIEVVS ARSVDFSHEP NLFGLFANRR AALQSLQNLA DEQKLCYGLL GLEPVSRGRA
CFRFALKRCA GACCGQETPQ AHFLRLQASL ERLRVVCWPW KGAIALKESR PQMTQFHIIN
NWLWLGAVPS LDEAATLVRT PAGFDQDGYK ILCKPLMSGQ YEIIELHTDC RQS