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Description:
DNA mismatch repair protein mutL.
Molecular weight: 67762
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
07-MAR-2006, entry version 49.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Salmonella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_SALTY:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | M29687 | AAA27166.1 | - |
| EMBL | AE008904 | AAL23179.1 | - |
| PIR | A33588 | A33588. | |
| HSSP | Q8XDN4 | 1NHH | |
| SMR | P14161 | 1-331, 435-616.1 | |
| GenomeReviews | AE006468_GR | STM4359.1 | |
| StyGene | SG10236 | mutL. | |
| BioCyc | STYP99287:STM4359-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX MEDLINE=90008766; PubMed=2676972;
RA Mankovich J.A., McIntyre C.A., Walker G.C.;
RT "Nucleotide sequence of the Salmonella typhimurium mutL gene required
RT for mismatch repair: homology of MutL to HexB of Streptococcus
RT pneumoniae and to PMS1 of the yeast Saccharomyces cerevisiae.";
RL J. Bacteriol. 171:5325-5331(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX MEDLINE=21534948; PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA Waterston R., Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT LT2.";
RL Nature 413:852-856(2001).
Feature:
CHAIN 1 618 DNA mismatch repair protein mutL.
/FTId=PRO_0000177967.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex.
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 618
MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RVDIDIERGG AKLIRIRDNG
CGIKKEELAL ALARHATSKI ASLDDLEAII SLGFRGEALA SISSVSRLTL TSRTAEQAEA
WQAYAEGRDM DVTVKPAAHP VGTTLEVLDL FYNTPARRKF MRTEKTEFNH IDEIIRRIAL
ARFDVTLNLS HNGKLVRQYR AVAKDGQKER RLGAICGTPF LEQALAIEWQ HGDLTLRGWV
ADPNHTTTAL TEIQYCYVNG RMMRDRLINH AIRQACEDKL GADQQPAFVL YLEIDPHQVD
VNVHPAKHEV RFHQSRLVHD FIYQGVLSVL QQQTETALPL EEIAPAPRHV QENRIAAGRN
HFAVPAEPTA AREPATPRYS GGASGGNGGR QSAGGWPHAQ PGYQKQQGEV YRTLLQTPTA
SPAPESVTPA LDGHSQSFGR VLTIVGGDCA LLEHAGTIQL LSLPVAERWL RQAQLTPGQS
PVCAQPLLIP LRLKVSADEK AALQKAQSLL GELGIEFQSD AQHVTIRAVP LPLRQQNLQI
LIPELIGYLA QQTTFATVNI AQWIARNVQS EHPQWSMAQA ISLLADVERL CPQLVKAPPG
GLLQPVDLHS AMNALKHE