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Description:
DNA mismatch repair protein mutS.
Molecular weight: 95407
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2005, sequence version 1.
07-MAR-2006, entry version 8.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Salmonella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_SALTY:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | M18965 | AAA27167.1 | ALT_FRAME |
| EMBL | U16303 | AAA80578.1 | ALT_FRAME |
| EMBL | AE008832 | AAL21789.1 | - |
| PIR | A28668 | A28668. | |
| HSSP | P23909 | 1NG9 | |
| SMR | P0A1Y0 | 7-802.1 | |
| GenomeReviews | AE006468_GR | STM2909.1 | |
| StyGene | SG10237 | mutS. | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-5.
RX MEDLINE=88086868; PubMed=3275609;
RA Haber L.T., Pang P.P., Sobell D.I., Mankovich J.A., Walker G.C.;
RT "Nucleotide sequence of the Salmonella typhimurium mutS gene required
RT for mismatch repair: homology of MutS and HexA of Streptococcus
RT pneumoniae.";
RL J. Bacteriol. 170:197-202(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=95302986; PubMed=7783645;
RA Mills D.M., Bajaj V., Lee C.A.;
RT "A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion
RT genes is absent from the corresponding region of the Escherichia coli
RT K-12 chromosome.";
RL Mol. Microbiol. 15:749-759(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX MEDLINE=21534948; PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA Waterston R., Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT LT2.";
RL Nature 413:852-856(2001).
RN [4]
RP MUTAGENESIS, AND ATP-BINDING.
RX MEDLINE=91330898; PubMed=1651234;
RA Haber L.T., Walker G.C.;
RT "Altering the conserved nucleotide binding motif in the Salmonella
RT typhimurium MutS mismatch repair protein affects both its ATPase and
RT mismatch binding activities.";
RL EMBO J. 10:2707-2715(1991).
RN [5]
RP IDENTIFICATION OF PROBABLE FRAMESHIFT IN 394-425.
RX MEDLINE=94087727; PubMed=7903399;
RA Claverie J.-M.;
RT "Detecting frame shifts by amino acid sequence comparison.";
RL J. Mol. Biol. 234:1140-1157(1993).
Feature:
CHAIN 1 855 DNA mismatch repair protein mutS.
/FTId=PRO_0000115132.
NP_BIND 616 623 ATP (Potential).
MUTAGEN 622 622 K->A: Defective in mismatch repair;
ATPase activity reduced 6-fold.
CONFLICT 361 362 TA -> S (in Ref. 1 and 2).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity.
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
-!- CAUTION: Ref.1 and Ref.2 sequences differ from that shown due to
frameshifts in positions 353, 379, 394, 422 and 425.
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Sequence length: 855
MNESFDKDFS NHTPMMQQYL KLKAQHPEIL LFYRMGDFYE LFYDDAKRAS QLLDISLTKR
GASAGEPIPM AGIPHHAVEN YLAKLVNQGE SVAICEQIGD PATSKGPVER KVVRIVTPGT
ISDEALLQER QDNLLAAIWQ DGKGYGYATL DISSGRFRLS EPADRETMAA ELQRTNPAEL
LYAEDFAEMA LIEGRRGLRR RPLWEFEIDT ARQQLNLQFG TRDLVGFGVE NASRGLCAAG
CLLQYVKDTQ RTSLPHIRSI TMERQQDSII MDAATRRNLE ITQNLAGGVE NTLAAVLDCT
VTPMGSRMLK RWLHMPVRNT DILRERQQTI GALQDTVSEL QPVLRQVGDL ERILARLALR
TARPRDLARM RHAFQQLPEL HAQLETVDSA PVQALRKKMG DFAELRDLLE RAIIDAPPVL
VRDGGVIAPG YHEELDEWRA LADGATDYLD RLEIRERERT GLDTLKVGYN AVHGYYIQIS
RGQSHLAPIN YVRRQTLKNA ERYIIPELKE YEDKVLTSKG KALALEKQLY DELFDLLLPH
LADLQQSANA LAELDVLVNL AERAWTLNYT CPTFTDKPGI RITEGRHPVV EQVLNEPFIA
NPLNLSPQRR MLIITGPNMG GKSTYMRQTA LIALLAYIGS YVPAQNVEIG PIDRIFTRVG
AADDLASGRS TFMVEMTETA NILHNATENS LVLMDEIGRG TSTYDGLSLA WACAENLANK
IKALTLFATH YFELTQLPEK MEGVANVHLD ALEHGDTIAF MHSVQDGAAS KSYGLAVAAL
AGVPKEVIKR ARQKLRELES ISPNAAATQV DGTQMSLLAA PEETSPAVEA LENLDPDSLT
PRQALEWIYR LKSLV