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Description:
A/G-specific adenine glycosylase (EC 3.2.2.-).
Molecular weight: 39409
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-FEB-1994, sequence version 1.
07-MAR-2006, entry version 45.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Salmonella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTY_SALTY:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | M86634 | AAA27165.1 | - |
| EMBL | AE008843 | AAL21985.1 | - |
| PIR | A40647 | A40647. | |
| HSSP | P17802 | 1KG5 | |
| SMR | Q05869 | 1-225.1 | |
| GenomeReviews | AE006468_GR | STM3110.1 | |
| StyGene | SG10238 | mutY. | |
| BioCyc | STYP99287:STM3110-MONOMER | -.1 | |
| InterPro | IPR003265 | Endo_3c. | |
| InterPro | IPR004035 | EndoIII_FCL. | |
| InterPro | IPR004036 | EndoIII_HhH. | |
| InterPro | IPR003651 | FeS_bind. | |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR013003 | MutY. | |
| InterPro | IPR005760 | MutY_bac. | |
| PANTHER | PTHR10359:SF3 | MutY.1 | 1. |
| Pfam | PF00633 | HHH | 1. |
| Pfam | PF00730 | HhH-GPD | 1. |
| SMART | SM00478 | ENDO3c | 1. |
| SMART | SM00525 | FES | 1. |
| TIGRFAMs | TIGR01084 | mutY | 1. |
| PROSITE | PS00764 | ENDONUCLEASE_III_1 | 1. |
| PROSITE | PS01155 | ENDONUCLEASE_III_2 | 1. |
Keywords:
4Fe-4S; Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase; Iron; Iron-sulfur; Metal-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=GW1803;
RX MEDLINE=93123173; PubMed=8419300;
RA Desiraju V., Shanabruch W.G., Lu A.L.;
RT "Nucleotide sequence of the Salmonella typhimurium mutB gene, the
RT homolog of Escherichia coli mutY.";
RL J. Bacteriol. 175:541-543(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX MEDLINE=21534948; PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA Waterston R., Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT LT2.";
RL Nature 413:852-856(2001).
Feature:
CHAIN 1 350 A/G-specific adenine glycosylase.
/FTId=PRO_0000102235.
METAL 192 192 Iron-sulfur (4Fe-4S) (By similarity).
METAL 199 199 Iron-sulfur (4Fe-4S) (By similarity).
METAL 202 202 Iron-sulfur (4Fe-4S) (By similarity).
METAL 208 208 Iron-sulfur (4Fe-4S) (By similarity).
Comments:
-!- FUNCTION: Adenine glycosylase active on G-A and C-A mispairs.
-!- COFACTOR: Binds 1 4Fe-4S cluster which is not important for the
catalytic activity, but which is probably involved in the proper
positioning of the enzyme along the DNA strand (By similarity).
-!- SIMILARITY: Belongs to the nth/mutY family.
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Sequence length: 350
MQASQFSAQV LDWYDKYGRK TLPWQINKTP YKVWLSEVML QQTQVTTVIP YFERFMARFP
TVTDLANAPL DEVLHLWTGL GYYARARNLH KAAQQVATLH GGEFPQTFAE IAALPGVGRS
TAGAILSLAL GKHYPILDGN VKRVLARCYA VSGWPGKKEV ENTLWTLSEQ VTPARGVERF
NQAMMDLGAM VCTRSKPKCT LCPLQNGCIA AAHESWSRYP GKKPKQTLPE RTGYFLLLQH
NQEIFLAQRP PSGLWGGLYC FPQFAREDEL REWLAQRHVN ADNLTQLNAF RHTFSHFHLD
IVPMWLPVSS LDACMDEGSA LWYNLAQPPS VGLAAPVERL LQQLRTGAPV