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Description:
DNA replication and repair protein recF.
Molecular weight: 40383
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
23-JAN-2002, sequence version 2.
07-MAR-2006, entry version 44.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Salmonella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECF_SALTY:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | X62505 | CAA44366.1 | - |
| EMBL | AE008878 | AAL22695.1 | - |
| PIR | S21057 | S21057. | |
| HSSP | P58301 | 1F2T | |
| GenomeReviews | AE006468_GR | STM3836.1 | |
| StyGene | SG10331 | recF. | |
| BioCyc | STYP99287:STM3836-MONOMER | -.1 | |
| HAMAP | MF_00365 | - | 1. |
| InterPro | IPR001238 | RecF. | |
| InterPro | IPR003395 | SMC_N. | |
| InterPro | IPR002017 | Spectrin. | |
| Pfam | PF02463 | SMC_N | 1. |
| TIGRFAMs | TIGR00611 | recf | 1. |
| PROSITE | PS00617 | RECF_1 | 1. |
| PROSITE | PS00618 | RECF_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=92178981; PubMed=1542576;
RA Sandler S.J., Chackerian B., Li J.T., Clark A.J.;
RT "Sequence and complementation analysis of recF genes from Escherichia
RT coli, Salmonella typhimurium, Pseudomonas putida and Bacillus
RT subtilis: evidence for an essential phosphate binding loop.";
RL Nucleic Acids Res. 20:839-845(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX MEDLINE=21534948; PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA Waterston R., Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT LT2.";
RL Nature 413:852-856(2001).
Feature:
INIT_MET 0 0 By similarity.
CHAIN 1 356 DNA replication and repair protein recF.
/FTId=PRO_0000196452.
NP_BIND 29 36 ATP (Potential).
CONFLICT 30 32 ANG -> PNA (in Ref. 1).
CONFLICT 106 107 EL -> DV (in Ref. 1).
CONFLICT 125 125 N -> T (in Ref. 1).
CONFLICT 165 165 R -> A (in Ref. 1).
CONFLICT 257 259 IRA -> MLC (in Ref. 1).
CONFLICT 286 286 E -> Q (in Ref. 1).
CONFLICT 295 295 Missing (in Ref. 1).
CONFLICT 302 302 D -> A (in Ref. 1).
CONFLICT 310 310 A -> G (in Ref. 1).
CONFLICT 330 332 AIS -> EL (in Ref. 1).
Comments:
-!- FUNCTION: The recF protein is involved in DNA metabolism; it is
required for DNA replication and normal SOS inducibility. RecF
binds preferentially to single-stranded, linear DNA. It also seems
to bind ATP.
-!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
-!- SIMILARITY: Belongs to the recF family.
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Sequence length: 356
SLTRLLIKDF RNIENADLAL SPGFNFLVGA NGSGKTSVLE AIYTLGHGRA FRSLQPGRVI
RHEQEAFVLH GRLQSEERET SIGLTKDKQG DSKVRIDGTD GHKIAELAHL MPMQLITPEG
FTLLNGGPKY RRAFLDWGCF HNEAGFFTAW SNLKRLLKQR NAALRQVSRY EQLRPWDKEL
IPLAEQISTW RAEYSSAIAQ DMADTCQQFL PEFSLTFSFQ RGWEKETDYA DVLERSFERD
RMLTYTAHGP HKADFRIRAD GAPVEDTLSR GQLKLLMCAL RLAQGEFLTR ESGRRCLYLI
DDFASELDDA RRGLLASRLK ATQSQVFVSA ISAEHVIDMS DENSKMFTVE KGKITD