Description:
ATP-dependent DNA helicase rep (EC 3.6.1.-).
Molecular weight: 77171
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 26.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Salmonella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein REP_SALTY:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF233324 | AAF33474.1 | - |
| EMBL | AE008882 | AAL22762.1 | - |
| HSSP | P09980 | 1UAA | |
| GenomeReviews | AE006468_GR | STM3912.1 | |
| StyGene | SG????? | rep. | |
| BioCyc | STYP99287:STM3912-MONOMER | -.1 | |
| InterPro | IPR005752 | DNA_hel_RepA. | |
| InterPro | IPR000212 | UvrD-helicase. | |
| PANTHER | PTHR11070 | UvrD-helicase.1 | 1. |
| Pfam | PF00580 | UvrD-helicase | 1. |
| TIGRFAMs | TIGR01074 | rep | 1. |
Keywords:
ATP-binding; Complete proteome; DNA replication; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX MEDLINE=21534948; PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA Waterston R., Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT LT2.";
RL Nature 413:852-856(2001).
Feature:
CHAIN 1 674 ATP-dependent DNA helicase rep.
/FTId=PRO_0000102070.
NP_BIND 22 29 ATP (By similarity).
Comments:
-!- FUNCTION: Rep helicase is a single-stranded DNA-dependent ATPase
involved in DNA replication; it can initiate unwinding at a nick
in the DNA. It binds to the single-stranded DNA and acts in a
progressive fashion along the DNA in the 3' to 5' direction (By
similarity).
-!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
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Sequence length: 674
MRLNPGQQHA VEFVTGPCLV LAGAGSGKTR VITNKIAHLI RGCGYQARHI AAVTFTNKAA
REMKERVGQT LGRKEARGLM ISTFHTLGLD IIKREYAALG MKSNFSLFDD TDQVALLKEL
TEGLIEDDKV LLQQLISTIS NWKNDLKTPA QAAAGAKGER DRIFAHCYGL YDAHMKACNV
LDFDDLILLP TLLLQRNDEV RERWQNKIRY LLVDEYQDTN TSQYELVKLL VGQRARFTVV
GDDDQSIYSW RGARPQNLVL LSQDFPALQV IKLEQNYRSS GRILKAANIL IANNPHVFEK
RLFSELGYGA ELKVLSANNE EHEAERVTGE LIAHHFVNKT QYKDYAILYR GNHQSRVFEK
FLMQNRIPYK ISGGTSFFSR PEIKDLLAYL RVLTNPDDDS AFLRIVNTPK REIGPATLQK
LGEWAMTRNK SLFTASFDMG LSQKLTGRGY DSLTRFTHWL GEIQRLAERE PVAAVRDLIH
GIDYESWLYE TSPSPKAAEM RMKNVNQLFS WMTEMLEGNE LDEPMTLTQV VTRFTLRDMM
ERGESEEELD QVQLMTLHAS KGLEFPYVYM VGMEEGFLPH QSSIDEDNIE EERRLAYVGI
TRAQKELTFT LCKERRQYGE LVRPEPSRFL LELPQDDLIW EQERKVVSAE ERMQKGQSHL
ANLKAMMAAK RAKS