Description:
Protein umuD (EC 3.4.21.-) [Contains: Protein umuD'].
Molecular weight: 15289
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
01-AUG-1991, sequence version 1.
07-MAR-2006, entry version 47.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Salmonella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UMUD_SALTY:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | M57431 | AAA27247.1 | - |
| EMBL | AE008788 | AAL20908.1 | - |
| PIR | A36713 | A36713. | |
| HSSP | P04153 | 1I4V | |
| SMR | P22493 | 32-137.1 | |
| MEROPS | S24.003 | -. | |
| GenomeReviews | AE006468_GR | STM1998.1 | |
| StyGene | SG10411 | umuD. | |
| BioCyc | STYP99287:STM1998-MONOMER | -.1 | |
| InterPro | IPR006198 | Pept_S24_S26. | |
| InterPro | IPR006197 | Pept_S24_SOS. | |
| Pfam | PF00717 | Peptidase_S24 | 1. |
| PRINTS | PR00726 | LEXASERPTASE. |
Keywords:
Autocatalytic cleavage; Complete proteome; DNA damage; DNA repair; Hydrolase; Protease; Serine protease; SOS mutagenesis; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX MEDLINE=90368548; PubMed=2144275;
RA Smith C.M., Koch W.H., Franklin S.B., Foster P.L., Cebula T.A.,
RA Eisenstadt E.;
RT "Sequence analysis and mapping of the Salmonella typhimurium LT2 umuDC
RT operon.";
RL J. Bacteriol. 172:4964-4978(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX MEDLINE=90368549; PubMed=2203737;
RA Thomas S.M., Crowne H.M., Pidsley S.C., Sedgwick S.G.;
RT "Structural characterization of the Salmonella typhimurium LT2 umu
RT operon.";
RL J. Bacteriol. 172:4979-4987(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX MEDLINE=21534948; PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA Waterston R., Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT LT2.";
RL Nature 413:852-856(2001).
RN [4]
RP PROCESSING.
RX MEDLINE=91375454; PubMed=1910151;
RA Woodgate R., Levine A.S., Koch W.H., Cebula T.A., Eisenstadt E.;
RT "Induction and cleavage of Salmonella typhimurium UmuD protein.";
RL Mol. Gen. Genet. 229:81-85(1991).
Feature:
CHAIN 1 139 Protein umuD.
/FTId=PRO_0000041989.
CHAIN 25 139 Protein umuD'.
/FTId=PRO_0000027307.
ACT_SITE 60 60 Involved in auto-cleavage (By
similarity).
ACT_SITE 97 97 Involved in auto-cleavage (By
similarity).
SITE 24 25 Cleavage (auto-).
Comments:
-!- FUNCTION: Involved in UV protection and mutation. Essential for
induced (or SOS) mutagenesis. May modify the DNA replication
machinery to allow bypass synthesis across a damaged template.
-!- SIMILARITY: Belongs to the peptidase S24 family.
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Sequence length: 139
MEFFRPTELR EIIPLPFFSY LVPCGFPSPA ADYIEQRIDL NELLVSHPSS TYFVKASGDS
MIEAGISDGD LLVVDSSRNA DHGDIVIAAI EGEFTVKRLQ LRPTVQLIPM NGAYRPIPVG
SEDTLDIFGV VTFIIKAVS