Description:
Probable DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-methyladenine DNA glycosidase).
Molecular weight: 23773
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
07-FEB-2006, entry version 18.
Phylogenetic order:
Eukaryota Fungi Microsporidia Unikaryonidae Encephalitozoon.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein 3MG_ENCCU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL590445 | CAD26679.1 | - |
| EMBL | AL590450 | CAD25924.1 | - |
| HSSP | P29372 | 1EWN | |
| InterPro | IPR003180 | PurDNA_glycsylse. | |
| PANTHER | PTHR10429 | PurDNA_glycsylse.1 | 1. |
| Pfam | PF02245 | Pur_DNA_glyco | 1. |
| TIGRFAMs | TIGR00567 | 3mg | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Hydrolase; Nuclear protein.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GB-M1;
RX MEDLINE=21576510; PubMed=11719806; DOI=10.1038/35106579;
RA Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M.,
RA Weissenbach J., Vivares C.P.;
RT "Genome sequence and gene compaction of the eukaryote parasite
RT Encephalitozoon cuniculi.";
RL Nature 414:450-453(2001).
Feature:
CHAIN 1 208 Probable DNA-3-methyladenine glycosylase.
/FTId=PRO_0000100069.
Comments:
-!- FUNCTION: Hydrolysis of the deoxyribose N-glycosidic bond to
excise 3-methyladenine, and 7-methylguanine from the damaged DNA
polymer formed by alkylation lesions (By similarity).
-!- CATALYTIC ACTIVITY: Hydrolysis of alkylated DNA, releasing 3-
methyladenine, 3-methylguanine, 7-methylguanine and 7-
methyladenine.
-!- SUBCELLULAR LOCATION: Nucleus (Potential).
-!- SIMILARITY: Belongs to the DNA glycosylase MPG family.
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Sequence length: 208
MDMGIPCSQL ARRLLGKMLC RRIEGRTTKG MIVETEAYLG KEDKACHSYG GRRTERNSAM
YMKAGTCYVY RIYGRYECFN ISSVEAGAGV LVRALEPLCG VSEMRERRGG RVKDRDIANG
PSKLCIAMGI TRREIDKEWI AGSEKIWLEE GREVADPEIV AGRRIGIRNC GEWEEKKLRF
YIRDNEFVSC IRRRELGNRK HGSVQQLP