|
|
|
|
|
|
Description:
MutS protein homolog 5.
Molecular weight: 1531
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
mismatch repair( GO:0006298 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
27-MAY-2002, sequence version 2.
21-FEB-2006, entry version 39.
Phylogenetic order:
Eukaryota Metazoa Nematoda Chromadorea Rhabditida Rhabditoidea Rhabditidae Peloderinae Caenorhabditis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MSH5_CAEEL:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF271389 | AAF76200.1 | - |
| EMBL | Z73896 | CAA98059.2.1 | - |
| EMBL | AF070070 | AAC70065.1 | - |
| PIR | T43201 | T43201. | |
| HSSP | Q56215 | 1EWQ | |
| GermOnline | 194143 | -.1 | |
| Ensembl | F09E8.3 | Caenorhabditis elegans.1 | |
| WormBase | WBGene00003421 | msh-5.1 | |
| WormPep | F09E8.3 | CE26678. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA-binding; Meiosis; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=Bristol N2;
RX MEDLINE=20469350; PubMed=11014811;
RA Kelly K.O., Dernburg A.F., Stanfield G.M., Villeneuve A.M.;
RT "Caenorhabditis elegans msh-5 is required for both normal and
RT radiation-induced meiotic crossing over but not for completion of
RT meiosis.";
RL Genetics 156:617-630(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RT "Genome sequence of the nematode C. elegans: a platform for
RT investigating biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP SEQUENCE REVISION.
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-933.
RX MEDLINE=99005534; PubMed=9787078; DOI=10.1006/geno.1998.5447;
RA Winand N.J., Panzer J.A., Kolodner R.D.;
RT "Cloning and characterization of the human and Caenorhabditis elegans
RT homologs of the Saccharomyces cerevisiae MSH5 gene.";
RL Genomics 53:69-80(1998).
Feature:
CHAIN 1 1369 MutS protein homolog 5.
/FTId=PRO_0000115205.
NP_BIND 639 646 ATP (Potential).
Comments:
-!- FUNCTION: Crucial component in meiotic recombination, functioning
at some point after the initiation step of recombination. Plays a
role in promoting the crossover outcome of meiotic recombination
events. Required for formation of normal meiotic crossover, and
crossover and chiasmata generated by artifically made DNA breaks.
-!- SUBUNIT: Heterooligomer of MSH4 and MSH5 (By similarity).
-!- TISSUE SPECIFICITY: Germline specific expression.
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 1369
MSTRWRYYNS KRGNGFRGRG RGRGRGTSLT AVALPRDDNF HKGAQDGAYF KDMPMDPEQF
RDETVLSLSF AQGMLGAAYY EQSSQLLKIM NDISEDLEFR FLKRLIDDVK PTLIIANRSQ
DLEFIKFLTT RYDPQEKIYE DGTTEEGTSE DTVPTWDSSL AYSTDETTAE KEEKEEDEDD
DDEGLPAKLN KLPNNFFRMS RAIERLKAMA GSHDSSMTEE DKYIIIKMRF DIEAVNMIRS
FGALLLFLDE TRMGVTDDPL SVTSPIKSIK TFTLGNLVEI DFNTIQALDI LPKETENKKT
FGQGRSLYQL MDKCRSTVGK KCLRKWFRNP TTDRDDLVSR QKCVHYFKQD WNAEVTAKLS
SILGRVKALN SVFQKFQSGT AQLIHWECFV STVNALVEIL NIIRQTPISK EFPVESDLLR
EVSEIAVIAG SIINFAESKI QGRVTVMNGI DEELDEIRDT YENMPMVLTA IAKQEEARLG
LPPYSNVACV YIPLVGFVLS VPRDYGVESQ PDMTLLYSTH EDLRVRNATT SRLDDEFGDI
LMRLIDSQTA IILTLKTRVM KKKRSIIKLL SIASRIDVLI SFGLIAAQNG WNCPALVDEP
VIEAVELYHP ISVLVVKKSF VPNQVSSGRD GIKASIITGP NACGKSVYMK SIGIMVFLSH
IGSFVPARHA KIGIVDRIVT RMFTVDSVLD GMSTFAKDVE QVALALRKAT GNSLVIIDEF
GKGTMTEVGL SLLASVMTYW MNRGADRCPH IFLSSHFHAL PNYIPLETNI ATFLTFTVLR
EAGGKIKYLF RMTPGLVDCS FALSVAKEEG IPPPVIGRAC RIYKALKAGT LLKEIKAEVS
NDNEKQLVED MDVVLADEDG FMAAVESFVK RKKTSFCESS MRNVSEEIEK ERSEASTPAS
KSRSTITARS NSVLSSRSMA SVDQLSVLDA LLPKKKKKKV TGSSMESSMS PDPFQEEDEG
TEGEEDQISA PVSRPTLPSV QKYASEEEKQ QSINSRHSFS TRTAIHIPTP IQMGEAGGVK
RPRSTSTSSP GPSASKSVRT EVFKKTPNVK ESQVLETPKQ LSISSFLEPK FPSSEKDVIS
RVSERYLQSD PFKTPISDRR SQQSSRHSTP KNRSMNQSLI QSARDTPHET IRSSNEVNPE
FFNIFNFPDD SILKSQDTYD PNVTPRSSSR RELRPDVSHS QNSQFGEVFS ELGTQFSIFN
SQQSFPGNSM GTTNPDCSIF DDFFANSQDG EKKIDSTKTS MPIVNSDNFI FKTPEPRSSE
KQRSLLKNKG QASNSSISPS SLILGQLAFG DVDQTPRPRG DNPIEFQYDV VDDDDPIFEE
KNCSAPVFEF LKSNDDEEDD EFLKSFLETE GSLHIDTSAD ETIDRSKRS