Description:
Excinuclease cho (EC 3.1.25.-) (Endonuclease cho) (UvrC homologprotein).
Molecular weight: 33706
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
28-MAR-2003, sequence version 2.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Shigella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein CHO_SHIFL:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE005674 | AAN43077.1 | ALT_INIT |
| EMBL | AE016983 | AAP16970.1 | - |
| GenomeReviews | AE014073_GR | S1602.1 | |
| GenomeReviews | AE005674_GR | SF1485.1 | |
| BioCyc | SFLE198214:AAN43077.1-MONOMER | -.1 | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| SMART | SM00465 | GIYc | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; Hydrolase; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX MEDLINE=22272406; PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H.,
RA Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J.,
RA Sun L., Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S.,
RA Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y.,
RA Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2457T / ATCC 700930 / Serotype 2a;
RX MEDLINE=22590274; PubMed=12704152;
RX DOI=10.1128/IAI.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W.,
RA Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A.,
RA Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S.,
RA Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella
RT flexneri serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
Feature:
CHAIN 1 295 Excinuclease cho.
/FTId=PRO_0000138375.
Comments:
-!- FUNCTION: Incises the DNA at the 3' side of a lesion during
nucleotide excision repair. Incises the DNA farther away from the
lesion than uvrC. Not able to incise the 5' site of a lesion. When
a lesion remains because uvrC is not able to induce the 3'
incision, cho incises the DNA. Then uvrC makes the 5' incision.
The combined action of cho and uvrC broadens the substrate range
of nucleotide excision repair (By similarity).
-!- SIMILARITY: Contains 1 uvrC C-terminal domain.
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Sequence length: 295
MVRRLTSPRL EFEAAAIYEY PEHLHSFLND LPTRPGVYLF HGESDTMPLY IGKSVNIRSR
VLSHLRTPDE AAMLRQSRRI SWICTAGEIG ALLLEARLIK EQQPLFNKRL RRNRQLCALQ
LNEKRVDVVY AKEVDFSRAP NLFGLFANRR AALQALQSIA DEQKLCYGLL GLEPLSRGRA
CFRSALKRCA GACCGKESHE EHALRLRQSL ERLRVVCWPW QGAVALKEQH PEMTQYHIIQ
NWLWLGAVNS LEEATTLIRT PAGFDHDGYK ILCKPLLSGN YEITELDPAN DQRAS