Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 25559
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 35.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Yersinia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_YERPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AJ414153 | CAC92943.1 | - |
| EMBL | AE013730 | AAM84855.1 | ALT_INIT |
| EMBL | AE017136 | AAS62706.1 | ALT_INIT |
| PIR | AH0329 | AH0329. | |
| HSSP | P12295 | 1LQG | |
| SMR | Q8ZD85 | 5-226.1 | |
| GenomeReviews | AE009952_GR | y1281.1 | |
| GenomeReviews | AE017042_GR | YP2508.1 | |
| GenomeReviews | AL590842_GR | YPO2704.1 | |
| BioCyc | YPES187410:Y1281-MONOMER | -.1 | |
| BioCyc | YPES632:YPO2704-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX MEDLINE=21470413; PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G.,
RA Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V.,
RA Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M.,
RA Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX MEDLINE=22137863; PubMed=12142430;
RX DOI=10.1128/JB.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C.,
RA Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V.,
RA Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R.,
RA Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z.,
RA Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J.,
RA Yang H., Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
Feature:
CHAIN 1 228 Uracil-DNA glycosylase.
/FTId=PRO_0000176170.
ACT_SITE 64 64 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 228
MSPSLTWHDV IGQEKEQPYF KDTLAYVAAE RRAGKTIYPP QKDIFNAFRL TELDQVKVVI
LGQDPYHGPN QAHGLSFSVL PGVPAPPSLG NIYKELVTDI PGFQRPNHGF LQSWAEQGVL
LLNTVLTVEA GKAHSHANLG WETFTDKVIA ALNEHREGVI FMLWGSHAQK KGRIINTERH
YILKAPHPSP LSAHRGFLGC KHFSQANQLL QQQNQQPIDW QPKLPAVE