Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 68693
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 36.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Yersinia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_YERPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AJ414150 | CAC90683.1 | - |
| EMBL | AE013847 | AAM85999.1 | ALT_INIT |
| EMBL | AE017132 | AAS61762.1 | ALT_INIT |
| PIR | AG0227 | AG0227. | |
| HSSP | P07025 | 1E52 | |
| SMR | Q8ZF52 | 555-610.1 | |
| GenomeReviews | AE009952_GR | y2442.1 | |
| GenomeReviews | AE017042_GR | YP1527.1 | |
| GenomeReviews | AL590842_GR | YPO1866.1 | |
| BioCyc | YPES187410:Y2442-MONOMER | -.1 | |
| BioCyc | YPES632:YPO1866-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX MEDLINE=21470413; PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G.,
RA Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V.,
RA Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M.,
RA Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX MEDLINE=22137863; PubMed=12142430;
RX DOI=10.1128/JB.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C.,
RA Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V.,
RA Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R.,
RA Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z.,
RA Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J.,
RA Yang H., Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
Feature:
CHAIN 1 610 UvrABC system protein C.
/FTId=PRO_0000138364.
DOMAIN 204 239 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 610
MTDLFDYKEF LKTVTSQPGV YRMYDTAGTV IYVGKAKDLK KRLTSYFRAQ VANRKTETLV
KNIAQIDVTV THTETEALLL EHNYIKLYQP RYNVLLRDDK SYPLIFLSAD EHPRLAVHRG
AKHEKGEYFG PFPNSYAVRE TLALLQKLFP VRQCENSVYR NRSRPCLQYQ IGRCSGPCVE
GLVSEEEYQR QVDYVRLFLS GKDQQVLTQL ITRMEEASQQ LHFEDAARIR DQIQAVRRVT
EQQFVSGDSE DLDVIGVAFD AGLACVHVLF IRLGKVLGSR SYFPKVPAGT ELSEVVQTFV
GQFYLQGSQG RTLPGEILLD FTLTEKDLLA SSLSELAGRK IQIQSRPRGD RARYLKLART
NASTALITRL SQQSTIHQRM KELAKVLKLD EINRMECFDI SHTMGEQTVA SCVVFDANGP
VRSEYRRYNI SGITPGDDYA AMAQVLKRRY GKALDDQKIP DVIFIDGGKG QLSQAFDVFA
SLNVPWDKQK PLLVGVAKGS DRKAGLETLF LASEGEGFSL PPDSPALHLI QHIRDDSHNH
AITGHRQRRS KVKNTSALEM IEGVGPKRRQ VLLKYMGGLQ PLFNASVEEI AKVPGISQAL
AEKIHNALKH