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Description:
Probable DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase[ATP]).
Molecular weight: 66945
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
20-JUN-2001, sequence version 2.
07-MAR-2006, entry version 37.
Phylogenetic order:
Bacteria Aquificae Aquificales Aquificaceae Aquifex.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DNLI_AQUAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000657 | AAC07362.1 | ALT_INIT |
| PIR | D70421 | D70421. | |
| GenomeReviews | AE000657_GR | AQ_1394.1 | |
| BioCyc | AAEO63363:AQ_1394-MONOMER | -.1 | |
| HAMAP | MF_00407 | - | 1. |
| InterPro | IPR001251 | CRAL_bd_TRIO_C. | |
| InterPro | IPR000977 | DNA_ligase. | |
| InterPro | IPR012309 | DNA_ligase_A_C. | |
| InterPro | IPR012310 | DNA_ligase_A_M. | |
| InterPro | IPR012308 | DNA_ligase_A_N. | |
| PANTHER | PTHR10459 | DNA_ligase.1 | 1. |
| Pfam | PF04679 | DNA_ligase_A_C | 1. |
| Pfam | PF01068 | DNA_ligase_A_M | 1. |
| Pfam | PF04675 | DNA_ligase_A_N | 1. |
| TIGRFAMs | TIGR00574 | dnl1 | 1. |
| PROSITE | PS00697 | DNA_LIGASE_A1 | 1. |
| PROSITE | PS00333 | DNA_LIGASE_A2 | FALSE_NEG. |
| PROSITE | PS50160 | DNA_LIGASE_A3 | 1. |
Keywords:
ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex
RT aeolicus.";
RL Nature 392:353-358(1998).
Feature:
CHAIN 1 584 Probable DNA ligase.
/FTId=PRO_0000059623.
ACT_SITE 250 250 N6-AMP-lysine intermediate (By
similarity).
Comments:
-!- FUNCTION: This protein seals, during DNA replication, DNA
recombination and DNA repair, nicks in double-stranded DNA (By
similarity).
-!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) +
(deoxyribonucleotide)(m) = AMP + diphosphate +
(deoxyribonucleotide)(n+m).
-!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
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Sequence length: 584
MEYRILAEFY ERIEKTTSRI EMVSSLVELF KQTPKELIDK VVYLSIGKIA PEYTGLDYNF
GEKLAIRALS RVLKIPALEI EKRVRQEGDL GEAGRKLYEE LGFKPEGTLT VEEVYNGLLN
IAKAVGIGSQ ERKISIFASL LKKATPLEAK YLLRTITERL RLGIGDNTIL EALSIAFTGS
SVNREVVERA YNLTSDLGYV AKILAEKGLE GVKQVKIQVG RPVRPMLAER MSSPILILRK
LGGKCGAEYK YDGERIQAHR KGDEFYLFSR RLENITHQYP DLIEFLKEAI PHDFIVELEA
VVIDPASGEI RPFQELMHRK VKYVTKYHIT KYPVAGFLFD IIYLDGEDLT LKPYPERREI
LEKVVKRTDR IGLVPRKIVD NVEDLENFFY QAIEEGCEGL VCKSLAPNSI YQAGKRGFLW
IKYKRDYKSV LADTLDLVVV GGFYGKGQRK GTFGSLLMAC YDPESDMFKT VTKVGTGFTE
DDFKKLEEIL MPRKLNHRHP RVNSILEADM WFEPYLVLEI TGAELTLSPV HTCGWGKVSP
NRGIGLRFPR FTGRYRFDKR PEDATTEQEI IEMYRMQRKI RVRS