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Description:
DNA polymerase I (EC 2.7.7.7) (POL I).
Molecular weight: 65833
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
07-MAR-2006, entry version 37.
Phylogenetic order:
Bacteria Aquificae Aquificales Aquificaceae Aquifex.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DPO1_AQUAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000657 | AAC07735.1 | - |
| PIR | G70468 | G70468. | |
| HSSP | P00582 | 1KFD | |
| GenomeReviews | AE000657_GR | AQ_1967.1 | |
| BioCyc | AAEO63363:AQ_1967-MONOMER | -.1 | |
| InterPro | IPR002562 | 3_5_exonuclease. | |
| InterPro | IPR001098 | DNA_pol. | |
| InterPro | IPR002298 | DNA_polI. | |
| InterPro | IPR012337 | RNaseH_fold. | |
| Pfam | PF01612 | 3_5_exonuc | 1. |
| Pfam | PF00476 | DNA_pol_A | 1. |
| PRINTS | PR00868 | DNAPOLI. | |
| SMART | SM00474 | 35EXOc | 1. |
| SMART | SM00482 | POLAc | 1. |
| PROSITE | PS00447 | DNA_POLYMERASE_A | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex
RT aeolicus.";
RL Nature 392:353-358(1998).
Feature:
CHAIN 1 574 DNA polymerase I.
/FTId=PRO_0000101232.
Comments:
-!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
diphosphate + DNA(n+1).
-!- SIMILARITY: Belongs to the DNA polymerase type-A family.
-!- SIMILARITY: Contains 1 3'-5' exonuclease domain.
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Sequence length: 574
MDFEYVTGEE GLKKAIKRLE NSPYLYLDTE TTGDRIRLVQ IGDEENTYVI DLYEIQDIEP
LRKLINERGI VGHNLKFDLK YLYRYGIFPS ATFDTMIASY LLGYERHSLN HIVSNLLGYS
MDKSYQTSDW GASVLSDAQL KYAANDVIVL RELFPKMRDM LNELDAERGE ELLKTRTAKI
FDLKSPVAIV EMAFVREVAK LEINGFPVDV EELTNKLKAV ERETQKRIQE FYIKYRVDPL
SPKQLASLLT KKFKLNLPKT PKGNVSTDDK ALTSYQDVEP VKLVLEIRKL KKIADKLKEL
KEHLKNGRVY PEFKQIGAVT GRMSSAHPNI QNIHRDMRGI FKAEEGNTFV ISDFSQIELR
IAAEYVKDPL MLDAFKKGKD MHRYTASVVL GKKEEEITKE ERQLAKAINF GLIYGISAKG
LAEYAKLGYG VEISLEEAQV LRERFFKNFK AFKEWHDRVK KELKEKGEVK GHTLLGRRFS
ANTFNDAVNY PIQGTGADLL KLAVLLFDAN LQKKGIDAKL VNLVHDEIVV ECEKEKAEEV
KEILEKSMKT AGKIILKEVP VEVESVINER WTKD