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Description:
DNA mismatch repair protein mutL.
Molecular weight: 49594
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
07-MAR-2006, entry version 33.
Phylogenetic order:
Bacteria Aquificae Aquificales Aquificaceae Aquifex.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_AQUAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000657 | AAC07483.1 | - |
| PIR | D70436 | D70436. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE000657_GR | AQ_1578.1 | |
| BioCyc | AAEO63363:AQ_1578-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex
RT aeolicus.";
RL Nature 392:353-358(1998).
Feature:
CHAIN 1 425 DNA mismatch repair protein mutL.
/FTId=PRO_0000177924.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 425
MFVKLLPPEV RKVIAAGEVI ESPVDVVKEL VENSLDAKAT KVEVEIVKGG KRLIRVKDNG
TGIHPEDVEK VVLQGATSKI ETEKDLMNIS TYGFRGEALY SISSVSKFKL RSRFFQEKEG
KEIEVEAGNI LGTRRVGMPV GTEVEVRDLF FNLPVRRKFL KKEDTERRKV LELIKEYALT
NPEVEFTLFS EGRETLKLKK SSLKERVEEV FQTKTEELYA EREGITLRAF VSRNQRQGKY
YVFINKRPIQ NKNLKEFLRK VFGYKTLVVL YAELPPFMVD FNVHPKKKEV NILKERKFLE
LVRELAGKEK PIVDIPLSQP VKTYKPTYEI LGQMDETFIL VKDSEYLYFV DQHLLEERIN
YEKLKDENLA CRISVKAGQK LSEEKIRELI KTWRNLENPH VCPHGRPIYY KIPLREIYEK
VGRNY