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Description:
DNA mismatch repair protein mutS.
Molecular weight: 98366
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
07-MAR-2006, entry version 35.
Phylogenetic order:
Bacteria Aquificae Aquificales Aquificaceae Aquifex.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_AQUAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000657 | AAC06613.1 | - |
| PIR | H70327 | H70327. | |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE000657_GR | AQ_308.1 | |
| BioCyc | AAEO63363:AQ_308-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex
RT aeolicus.";
RL Nature 392:353-358(1998).
Feature:
CHAIN 1 859 DNA mismatch repair protein mutS.
/FTId=PRO_0000115063.
NP_BIND 607 614 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 859
MEKSEKELTP MLSQYHYFKN QYPDCLLLFR LGDFYELFYE DAYIGSKELG LVLTSRPAGK
GKERIPMCGV PYHSANSYIA KLVNKGYKVA ICEQVEDPSK AKGIVKREVV RVITPGTFFE
RDTGGLASLY KKGNHYYVGY LNLAVGEFLG AKVKIEELLD LLSKLNIKEI LVKKGEKLPE
ELEKVLKVYV SELEEEFFEE GSEEILKDFG VLSLQAFGFE EDTYSLPLGA VYKYAKTTQK
GYTPLIPRPK PYRDEGFVRL DIKAIKGLEI LESLEGRKDI SLFKVIDRTL TGMGRRRLKF
RLLSPFRSRE KIERIQEGVQ ELKENREALL KIRQILEGMA DLERLVSKIS SNMATPRELV
YLKNSLKKVE ELRLLLLELK APIFKEILQN FEDTKKIIND IEKTLVEDPP LHVKEGGLIR
EGVNAYLDEL RFIRDNAETY LREYEKKLRQ ETGIQSLKIG YNKVMGYYIE VTKPNLKYVP
SYFRRRQTLS NSERFTTEEL QRLEEKILSA QTRINDLEYE LYKELRERVV KELDKVGNNA
SAVAEVDFIQ SLAQIAYEKD WAKPQIHEGY ELIIEEGRHP VIEEFVENYV PNDTKLDRDS
FIHVITGPNM AGKSSYIRQV GVLTLLSHIG SFIPARRAKI PVVDALFTRI GSGDVLALGV
STFMNEMLEV SNILNNATEK SLVILDEVGR GTSTYDGIAI SKAIVKYISE KLKAKTLLAT
HFLEITELEG KIEGVKNYHM EVEKTPEGIR FLYILKEGKA EGSFGIEVAK LAGLPEEVVE
EARKILRELE EKENKKEDIV PLLEETFKKS EEAQRLEEYE EIIKKIEEID IGNTTPLQAL
LILAELKKKC SFSKKESGA