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Description:
Probable N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNAglycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase(EC 4.2.99.18) (AP lyase)].
Molecular weight: 26306
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
07-MAR-2006, entry version 35.
Phylogenetic order:
Bacteria Aquificae Aquificales Aquificaceae Aquifex.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein OGG1_AQUAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000657 | AAC06576.1 | - |
| PIR | H70322 | H70322. | |
| GenomeReviews | AE000657_GR | AQ_251.1 | |
| BioCyc | AAEO63363:AQ_251-MONOMER | -.1 | |
| HAMAP | MF_00241 | - | 1. |
| InterPro | IPR003265 | Endo_3c. | |
| InterPro | IPR012092 | Thrmst_ogg. | |
| Pfam | PF00730 | HhH-GPD | 1. |
| PIRSF | PIRSF005954 | Thrmst_ogg | 1. |
| SMART | SM00478 | ENDO3c | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase; Lyase; Multifunctional enzyme.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex
RT aeolicus.";
RL Nature 392:353-358(1998).
Feature:
CHAIN 1 226 Probable N-glycosylase/DNA lyase.
/FTId=PRO_0000159570.
ACT_SITE 149 149 By similarity.
Comments:
-!- FUNCTION: Responsible for removing an oxidatively damaged form of
guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks
DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).
-!- CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or
apyrimidinic site in DNA is broken by a beta-elimination reaction,
leaving a 3'-terminal unsaturated sugar and a product with a
terminal 5'-phosphate.
-!- SIMILARITY: Belongs to the type-2 OGG1 family.
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Sequence length: 226
MDAIQEVKRI IPEVQKYVNQ RMEEFERLGR EGWTHFDFRP FLDIDYDAGL FSELSFCILT
ANSSATLGIK IQAHLGEEGF LNKTKEELEE VFRKFGHRYA GQRAERIVEA REKFPKVKSL
IEKEKNSKVI RELLADPKSP YKIKGFGYKE ASHFLRNIGF KDLAIIDRHI SRFLMEKGLL
RQVKSITPKV YLEAEKALES LAKELGLSLG ELDLYIFYIK TKKVLK