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Description:
ATP-dependent DNA helicase recG (EC 3.6.1.-).
Molecular weight: 91180
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
07-MAR-2006, entry version 36.
Phylogenetic order:
Bacteria Aquificae Aquificales Aquificaceae Aquifex.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECG_AQUAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000657 | AAC07804.1 | - |
| PIR | A70476 | A70476. | |
| HSSP | Q9WY48 | 1GM5 | |
| GenomeReviews | AE000657_GR | AQ_2053.1 | |
| BioCyc | AAEO63363:AQ_2053-MONOMER | -.1 | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004365 | OB_tRNA_NA_bd. | |
| InterPro | IPR004609 | RecG. | |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF01336 | tRNA_anti | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00643 | recG | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex
RT aeolicus.";
RL Nature 392:353-358(1998).
Feature:
CHAIN 1 792 ATP-dependent DNA helicase recG.
/FTId=PRO_0000102137.
NP_BIND 388 395 ATP (Potential).
MOTIF 489 492 DEQH box.
Comments:
-!- FUNCTION: Critical role in recombination and DNA repair. Help
process Holliday junction intermediates to mature products by
catalyzing branch migration. Has a DNA unwinding activity
characteristic of a DNA helicase with a 3' to 5' polarity. RecG
unwind branched duplex DNA (Y-DNA) (By similarity).
-!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
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Sequence length: 792
MDTAFVKDFI DNLLENDGLK LKRAIGVGIF LFNKLKEDAP DYILESLKEV DKLPFEKKKA
VLREVRKFLS EYEKRKKEGN FLEKTKRKPI DVFFNPIEKV KILTKTQIST LKALGIETVY
DALFYFPEKY EDKRLNTSIK TAKVGEKVAL KVKVKEVKIK ENERYTLEVV CTDGTGYITL
KYRYKNPHFA LKAFRKGMEI VVYGKLKSFK GEKYMVHPEV KSPSSEELGK IIPVYYVRKR
GELQEISSKT KQKRVRTALT ALSESLYRYF PEYMPDYLIE KYNFPDIALC IKELHNPKDI
SVNALNSFTD LYHKRVIYDE LFLFQLALLL KKQEIKKEKA PKVNVDEKFL RKAIEKLPFK
LTRAQERAIK EILEDLSRDV PMNRLLQGDV GSGKTIVAIL TSLAVVKSGY QVAVMVPTEI
LAHQHYKKFS EMLKDYGVNV ALLTGSLTPS QKKSVYKHVK EGNIHVLVGT HALIQDKVEF
KNLGYVIIDE QHRFGVMQRK LLLEKGKGLY PHCLVMSATP IPRTLALSIY GDLDISIIDE
LPPGRKEVIT KLYFESQKEE VYKKVEEELK KGNKVYVIYP LIEESEKLNL KAATEEYERW
KKLFPDRKVL LLHGKMPDKE KLAVMEEFKR EGDILVSTTV IEVGIDVPEA TVMVIEDAHR
FGLSQLHQLR GRVGRSDKEA YCLLVVPDEI KNEKNESLKR LRVFVKTTDG FKIAEEDLKL
RGPGEIIGVS QSGYFGFRVA NLARSQDRAL LGVARKDAEE LLKNNPNLEN LQDLKKLLIK
KYGDKMELSF VA