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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10372
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
07-MAR-2006, entry version 41.
Phylogenetic order:
Bacteria Aquificae Aquificales Aquificaceae Aquifex.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_AQUAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000657 | AAC06874.1 | - |
| PIR | C70360 | C70360. | |
| GenomeReviews | AE000657_GR | AQ_686.1 | |
| BioCyc | AAEO63363:AQ_686-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 2. |
| ProDom | PD000006 | ABC_transporter | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex
RT aeolicus.";
RL Nature 392:353-358(1998).
Feature:
CHAIN 1 926 UvrABC system protein A.
/FTId=PRO_0000093033.
DOMAIN 340 568 ABC transporter 1.
DOMAIN 584 916 ABC transporter 2.
NP_BIND 31 38 ATP (Potential).
ZN_FING 251 278 C4-type.
NP_BIND 399 406 ATP 1 (Potential).
NP_BIND 620 627 ATP 2 (Potential).
ZN_FING 719 745 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 926
MDRIVIRGAR QHNLKNIDVE IPKNKLVVIT GPSGSGKSSL AFDTLYAEGQ RRYVESLSAY
ARQFLGVMEK PEVDSIEGLS PAIAIDQKTT SKNPRSTVGT VTEIYDYLRV LWANVGKPHC
PHCGNLLSGL SAHEILDRIV EKYKGKRVMI LSPIVRGKKG EFRELLRQIE KWGYSRVKVD
GELRRVIEVP PLEKNKKHTI ELVIDRLTVS EEERARLLED VEKALEFSSG LVKIEEVESG
KEELFSEKLV CPEHGFSIPE LSARLFSFNS PYGACPSCKG LGVKWEIDPA VLIDPEKPAV
KAVKIVESGY FNYLRFPIAN VIRKLGYDPR TPWKKLPESV RATVLYGSES LNFEGIIPHL
ERRFLEEESE RIREEIEDYI VEKPCPECKG ARLRKEALAV LIDGKSIWDV VNMPVGKAKE
FFEELYEKLE GKEKIIADRL LKEIIERLGF LVNVGLDYLS LSRSATTLSG GEMQRIRLAT
QLGSKLTGVL YVLDEPSIGL HPRDTSKLIN TLKGLRDLGN TVVVVEHDPE TIESADHVIE
LGPGAGKHGG YLVAQGTVEE IKSHPSSLTG AYLSGRKEIP VPKERRKPSG KFIRIVRAKE
HNLKNINVDI PLGLFVCITG VSGSGKSTLI YDILYKYAKN YFYGTHEQVG EVEKIEGLEN
IDKVINIDQS PIGRTPRSNP ATYTKVFDLI RNLFAQTPEA KARGYKPGRF SFNVKGGRCE
ACQGEGVIKV EMHFLPPVYV TCEVCKGKRY NRETLEITYK GKNIADVLEM TVDEAYDFFE
NHPAIRRKLQ ILKDVGLGYI KLGQPAPTLS GGEAQRIKLA RELSKKETGR TLYLLDEPTT
GLHMDDVKKL IDVLQRLVDK GNTVVVIEHN LDVIKCADWI IDLGPEGGER GGQVVAVGTP
EEVAQNPNSY TGKYLRKYLK KETLKV