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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 65596
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
07-MAR-2006, entry version 38.
Phylogenetic order:
Bacteria Aquificae Aquificales Aquificaceae Aquifex.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_AQUAE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000657 | AAC07850.1 | - |
| PIR | C70482 | C70482. | |
| GenomeReviews | AE000657_GR | AQ_2126.1 | |
| BioCyc | AAEO63363:AQ_2126-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex
RT aeolicus.";
RL Nature 392:353-358(1998).
Feature:
CHAIN 1 566 UvrABC system protein C.
/FTId=PRO_0000138286.
DOMAIN 199 234 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 566
MAKTGKVENL IQNAPEKPGV YLFKKGNRPI YIGKAKNLKK RLLQHLKASE YDSKERAIIS
NSDNLEWIVT RNEYEALVLE IDLIQQYKPR YNVLHKFGGG YPMLLLTKDE YPTIKVVRGT
EHEGELFGPF LQSKKAYKVK KLIHNLFKLR TCDPLPKRSE PCMDYHLGLC SAPCCGFVSK
EEYELAVSSA RALLTGEVAE VLPKLYEKIE EFSKELMFEK CAHIRDQIIA LENLAKGQAV
SALPFREGDI FYKFGSRLGL LLVRSSKLVS KEIFDLESDE EVEEVILGYY YSNYVPRKVI
TNFELSEEVK EWIRNRAKGE VEFSGEIPKE LKEVLEENLG EGINEEVLKK EFAEKLGMPV
PRVIEGFDIS HFYGEDIVGS CVVWKGGKMS KKDYRRYKVK TISRIDDYLA LEEVLTRRAK
RILKGEVEKP DIWLIDGGKG QLNVGIRVKK RTGLDVKVFS LAKEEEIIYT EDGREIRLKE
NPILYRVFGE IRDEAHRFAL SYNRKLREKR YMEDILSKIK GIGEQKKKII YKNFETLYDF
IEAKDEELRR LGINPSLKQE VKKWLS