Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 69849
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
19-OCT-2002, sequence version 2.
07-MAR-2006, entry version 28.
Phylogenetic order:
Bacteria Proteobacteria Betaproteobacteria Neisseriales Neisseriaceae Neisseria.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_NEIMA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL162756 | CAB84767.1 | ALT_INIT |
| GenomeReviews | AL157959_GR | NMA1540.1 | |
| BioCyc | NMEN65699:NMA1540-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z2491 / Serogroup A / Serotype 4A;
RX MEDLINE=20222556; PubMed=10761919; DOI=10.1038/35006655;
RA Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T.,
RA Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S.,
RA Jagels K., Leather S., Moule S., Mungall K.L., Quail M.A.,
RA Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Whitehead S., Spratt B.G., Barrell B.G.;
RT "Complete DNA sequence of a serogroup A strain of Neisseria
RT meningitidis Z2491.";
RL Nature 404:502-506(2000).
Feature:
CHAIN 1 617 UvrABC system protein C.
/FTId=PRO_0000138322.
DOMAIN 209 244 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 617
MNTENRSPEQ FDIPLFLKNL PKLPGVYRFF DEGGKVLYVG KAVNLKRRVS GYFQKNDHSP
RIALMVKQVH HIETTITRSE AEALILENNF IKALSPKYNI LFRDDKSYPY LMLSGHQYPQ
MAYYRGTLKK PNQYFGPYPN SNAVRDSIQI LQKVFMLRTC EDSVFEHRDR PCLLYQIKRC
TAPCVGHISE EDYRDSVRQA ATFLNGKTDE LTRTLQHKMQ TAAANLQFEE AARYRDQIQA
LGIMQSNQFI DSKNPNNPND IDLLALAVSD GLVCVHWVSI RGGRHVGDKS FFPDTKNDPE
PNGQDYAEAF VAQHYLGKSK PDIIINNFPV PDALKEALEG EHGKQMQFVT KTIGERKVWL
KMAEQNAQMA IAQRRLQQSN QQHRIDELAK ILGMDSDGLN RLECFDISHT QGEATIASCV
VYDEQNIQPS QYRRYNITTA KPGDDYAAMR EVLTRRYGKM QEAEANGETV KWPDAVLIDG
GKGQIGIAVS VWEELGLHIP LVGIAKGPER KAGMEELILP FTGEVFRLPP NSPALHLLQT
VRDESHRFAI TGHRKKRDKA RVTSSLSDIP GVGSKRRQAL LTRFGGLRGV IAASREDLEK
VEGISKALAE TIYEHLH