Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 25446
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 31.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Vibrionales Vibrionaceae Vibrio.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_VIBCH:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE004306 | AAF95502.1 | - |
| PIR | C82086 | C82086. | |
| HSSP | P12295 | 1LQM | |
| SMR | Q9KPK8 | 5-224.1 | |
| GenomeReviews | AE003852_GR | VC2359.1 | |
| TIGR | VC2359 | -. | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=El Tor N16961 / Serotype O1;
RX MEDLINE=20406833; PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A.,
RA Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L.,
RA Ermolaeva M.D., Vamathevan J.J., Bass S., Qin H., Dragoi I.,
RA Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D.,
RA Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R.,
RA Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
Feature:
CHAIN 1 226 Uracil-DNA glycosylase.
/FTId=PRO_0000176161.
ACT_SITE 64 64 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 226
MSESLTWHDV IGNEKQQAYF QQTLQFVESQ RQAGKVIYPP AKDVFNAFRF TEFGDVKVVI
LGQDPYHGPN QAHGLCFSVL PGVKTPPSLV NIYKELAQDI PGFQIPPHGY LQSWAQQGVL
LLNTVLTVEQ GMAHSHANTG WETFTDRVID ALNQHRNGLI FLLWGSHAQK KGQMIDRQRH
HVLMAPHPSP LSAHRGFLGC RHFSKTNQLL QAQGIAPINW QPELES