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Description:
DNA mismatch repair protein mutH (Methyl-directed mismatch repairprotein).
Molecular weight: 25525
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
07-MAR-2006, entry version 15.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Vibrionales Vibrionaceae Vibrio.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTH_VIBPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000031 | BAC58781.1 | - |
| GenomeReviews | BA000031_GR | VP0518.1 | |
| HAMAP | MF_00759 | - | 1. |
| InterPro | IPR004230 | MutH. | |
| Pfam | PF02976 | MutH | 1. |
| TIGRFAMs | TIGR02248 | mutH_TIGR | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633 / Serotype O3:K6;
RX MEDLINE=22508454; PubMed=12620739; DOI=10.1016/S0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
Feature:
CHAIN 1 226 DNA mismatch repair protein mutH.
/FTId=PRO_0000198677.
Comments:
-!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated
GATC sequences. It is involved in DNA mismatch repair (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the mutH family.
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Sequence length: 226
MKPEPQSEAE LMERAHDIAG LSFAELADEA GMTVPENLKR DKGWVGQLLE WHLGAPAGSK
PQQDFSKLGI ELKSIPIGYN GRPLETTFVC VAPLTGVQGL TWETSHVRNK LSRVLWVPVE
GEREIPLAER RVGTPLIWSP DKEEEQILRN DWEELMEMIV FGKFDQISAR HGEALHLRPK
AANAKALTEA YSSNGKPMKT LPRGFYLRTQ FTEQILLKHY INVQSE