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Description:
DNA mismatch repair protein mutL.
Molecular weight: 74919
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
23-MAY-2003, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Vibrionales Vibrionaceae Vibrio.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_VIBPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000031 | BAC61082.1 | - |
| HSSP | P23367 | 1BKN | |
| SMR | Q87L05 | 1-329.1 | |
| GenomeReviews | BA000031_GR | VP2819.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633 / Serotype O3:K6;
RX MEDLINE=22508454; PubMed=12620739; DOI=10.1016/S0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
Feature:
CHAIN 1 669 DNA mismatch repair protein mutL.
/FTId=PRO_0000177991.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 669
MTIKILPARL ANQIAAGEVV ERPASVIKEL VENSLDSGAT RIDIDIEKGG AKLIRVRDNG
KGIAKDELGL ALSRHATSKI HTLDDLEAIM SLGFRGEALA SISSVSRLTL TSRPAAQEEA
WSAYSEGRDM QVKLQPAAHP IGTTVEVLDL FFNTPARRKF LRTEKTEFAH IDELLKRIAL
SRFDVSINVR HNGKVIRQYR AAKNQLQTEK RIAAVCGNAF VRNMLRIELE HQGLKLHGWI
TTPDGARQQS DLQYCYVNGR MMRDKLINHA IRQSYEMSLK PDQFAAYVLF IELDPHQVDV
NVHPAKHEVR FHQARLVHDF IYQALADALA QSSVIDKPQV NESAFHRAEP EERESQPETT
PQYSPQSVST TVPERVYQAI DKTPTYPGRT DYEIKPRDRA PSDSSVREAR IADSFKRTDW
IESKLAPKPN VGKERHAEPA PSKREVHAYH ELLKTPDFES QQAEQPTSIE SVREVSLPQV
TALGKALVVV DEQFVLMSSD SGVALVSLPR SEFYRTKGQL TPSEGALKAQ PLLVPLSMKL
DTDLVRLAQD YQQDFAQLGI QLKARNDKAL MVMGVPAPLR QQNLQNLVPD LLSYAQTWMK
GEKASTQMLP ALIDWLAVQV TTVKSHYTLS EAIQIIAELE QLRHGQLPLD DKTFVSAVDF
SATIAKLKP