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Description:
DNA mismatch repair protein mutS.
Molecular weight: 94972
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
23-MAY-2003, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Vibrionales Vibrionaceae Vibrio.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_VIBPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000031 | BAC60815.1 | - |
| HSSP | P23909 | 1NG9 | |
| SMR | Q87LQ9 | 7-798.1 | |
| GenomeReviews | BA000031_GR | VP2552.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633 / Serotype O3:K6;
RX MEDLINE=22508454; PubMed=12620739; DOI=10.1016/S0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
Feature:
CHAIN 1 853 DNA mismatch repair protein mutS.
/FTId=PRO_0000115165.
NP_BIND 613 620 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 853
MKAEQKHTPM MQQYLKLKAE NPEILLFYRM GDFYELFYDD AKRASQLLDI SLTKRGSSAG
EPIPMAGVPF HAVEGYLAKL VQLGESVAIC EQIGDPATSK GPVERKVVRI VTPGTVTDEA
LLSERLDNLI AAIYHHNGKF GYATLDVTSG RFQLTEPETE EAMMAELQRT APRELLFPED
FEPVHLMSNR NGNRRRPVWE FELDTAKQQL NQQFGTRDLV GFGVEHASLG LCAAGCLIQY
VKDTQRTALP HIRSLTFDRQ DHSVILDAAT RRNLEITQNL AGGTDNTLAA VLDHCSTPMG
SRMLKRWLHQ PMRCIDTLNN RLDAIGEIKD QGLFTDLQPT LKQIGDIERI LARLALRSAR
PRDMARLRHA MQQLPELESL TASLTHPYLV KLAQYAAPID EVCELLERAI KENPPVVIRD
GGVIAEGYNE ELDEWRKLAD GATEYLEKLE ADERERHGID TLKVGYNAVH GFFIQVSRGQ
SHLVPPHYVR RQTLKNAERY IIPELKEHED KVLNSKSKAL ALEKKLWEEL FDLLMPHLEQ
MQNLASAVSQ MDVLQNLAER ADSLDYCRPT LVKDAGIHIQ AGRHPVVEQV TSDPFIANPI
ELSPSRKMLI ITGPNMGGKS TYMRQTALIA LMAHIGSYVP AESAQIGSLD RIFTRIGASD
DLASGRSTFM VEMTETANIL HNATKNSLVL MDEIGRGTST YDGLSLAWAS AEWLATQIGA
MTLFATHYFE LTELPNLLPN LANVHLDAVE HGDSIAFMHA VQEGAASKSY GLAVAGLAGV
PKTVIKNART KLSQLEQLGQ ASDSPRPSTV DVANQLSLIP EPSEIEQALS NIDPDDLTPR
QALEELYRLK KML