|
|
|
|
|
|
Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10387
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
16-JUN-2003, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Vibrionales Vibrionaceae Vibrio.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_VIBPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000031 | BAC60975.1 | - |
| GenomeReviews | BA000031_GR | VP2712.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 2. |
| ProDom | PD000006 | ABC_transporter | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 2. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633 / Serotype O3:K6;
RX MEDLINE=22508454; PubMed=12620739; DOI=10.1016/S0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
Feature:
CHAIN 1 940 UvrABC system protein A.
/FTId=PRO_0000093112.
DOMAIN 340 592 ABC transporter 1.
DOMAIN 603 936 ABC transporter 2.
NP_BIND 31 38 ATP (Potential).
ZN_FING 252 279 C4-type.
NP_BIND 639 646 ATP (Potential).
ZN_FING 739 765 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 940
MDKIEVRGAR THNLKDINLT IPRDKLTVIT GLSGSGKSSL AFDTLYAEGQ RRYVESLSAY
ARQFLSLMEK PDVDHIEGLS PAISIEQKST SHNPRSTVGT ITEVYDYLRL LYARVGEPRC
PTHHAPLAAQ TVSQMVDKVL ELPEGSKMML LAPIVKERKG EHVKTLENLA AQGFIRARID
GETCDLSDPP TLELHKKHTI EVVVDRFKVR PDLQQRLAES FETTLELSGG IAVVAPMDGD
GEEIIFSANF ACPQCGYSMQ ELEPRLFSFN NPAGACGTCD GLGVQQYFDP SRVIQDDSLS
LAQGAIRGWD QKNYYYFQML TSLADHYGFD LHAPFNSLPK KTQDVILKGS GRTEIEFKYI
NDRGDIRVKR HPFEGILNTL ERRYRDTESN SVREELAKYI STKSCSSCGG TRLRLEARNV
FIADTTLPEI VELSIADALT FFQTLKLEGQ RAQIAEKVMK EINDRLQFLV NVGLNYLNLS
RSAETLSGGE AQRIRLASQI GAGLVGVMYV LDEPSIGLHQ RDNERLLKTL THLRDLGNTV
LVVEHDEDAI RCADHVIDIG PGAGVHGGNV VAEGTMDEII ANPNSLTGQY LSGAKEIAVP
KERTPRDPKK TVELLGATGN NLKNVDLSIP VGLFSCITGV SGSGKSTLIN DTFFKIAHTQ
LNGATTAHPS PYKSIKGLEH FDKVIDIDQS PIGRTPRSNP ATYTGIFTPI RELFAGTQES
RSRGYKPGRF SFNVRGGRCE ACQGDGVIKV EMHFLPDVYV PCDVCKGKRY NRETLEVRYK
GKTIDEVLEM TVEDARTFFD PVPAIARKLQ TLMDVGLSYI RLGQAATTLS GGEAQRVKLA
RELSKRDTGK TLYILDEPTT GLHFHDIQQL LTVLHRLRDH GNTVVVIEHN LDVIKTADWI
IDLGPEGGQG GGEIIAQGTP EDVSQIEGSH TARFLKPMLK