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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 69214
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
16-JUN-2003, sequence version 1.
07-MAR-2006, entry version 23.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Vibrionales Vibrionaceae Vibrio.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_VIBPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000031 | BAC60207.1 | - |
| SMR | Q87NC4 | 555-610.1 | |
| GenomeReviews | BA000031_GR | VP1944.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633 / Serotype O3:K6;
RX MEDLINE=22508454; PubMed=12620739; DOI=10.1016/S0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
Feature:
CHAIN 1 610 UvrABC system protein C.
/FTId=PRO_0000138359.
DOMAIN 204 239 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 610
MNPPFDSASF LKTVTHQPGV YRMYNADAVV IYVGKAKDLQ KRLSSYFRKK VDSEKTRALV
SNIAKIDVTV THTETEALIL EHNYIKQYLP KYNVLLRDDK SYPYILISGH KHPRLSMHRG
AKKRKGEYFG PYPDSGAVRE TLHLLQKIFP VRQCEDTVYS NRTRPCLMYQ IGRCAGPCVS
SIISDEEYAE LVGFVRLFLQ GKDQQVLKQL IEKMEVASQQ LRFEDAAKFR DQIQAIRRVQ
EQQYVSEDSM DDMDVLGFAQ ENGIACIHIL MIRQGKVLGS RSHFPKIPQN TSQQEVFDSF
LTQYYLSHNE ARTIPSRIIL NQELADDLEP IQKALSEVAG RKVHFHTSPT GARGRYLKLS
NTNALTAITT KINHKMTINQ RFKALRETLG MESIMRMECF DISHTMGEST IASCVVFNNE
GPVKQEYRRY NITGITGGDD YAAMGQALER RYSKQLDVEK IPDIIFIDGG KGQLNRAHEI
IAQYWGDWPK RPIMIGIAKG VTRKPGLETL ITVDGEEFNL PSDAPALHLI QHIRDESHNH
AIAGHRAKRG KTRRTSALEG IEGVGPKRRQ ALLKYMGGLQ ELKRASVEEI AKVPGISHSL
AEIIFQALKQ