Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 25447
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Vibrionales Vibrionaceae Vibrio.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_VIBVU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE016795 | AAO09057.1 | - |
| HSSP | P12295 | 1LQG | |
| SMR | Q8DEP7 | 5-220.1 | |
| GenomeReviews | AE016795_GR | VV10540.1 | |
| BioCyc | VVUL216895:VV10540-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMCP6;
RA Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H.,
RA Choy H.E.;
RT "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 226 Uracil-DNA glycosylase.
/FTId=PRO_0000176163.
ACT_SITE 64 64 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 226
MTQQLTWHDV IGAEKEQSYF QQTLNFVEAE RQAGKVIYPP AKDVFNAFRY TEFQDVKVVI
LGQDPYHGPN QAHGLCFSVL PGIKTPPSLV NMYKELAQDI QGFQIPAHGY LEAWAKQGVL
LLNTVLTVEQ GKAHSHASLG WETFTDKVIE AINQHQQGVV FLLWGSHAQK KGRFIDRHKH
VVLTAPHPSP LSAHRGFLGC KHFSQANQHL LDQGKQAIDW QLPLSL