Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 68990
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
23-APR-2003, integrated into UniProtKB/Swiss-Prot.
23-APR-2003, sequence version 2.
07-MAR-2006, entry version 18.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Vibrionales Vibrionaceae Vibrio.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_VIBVU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE016795 | AAO11377.1 | ALT_INIT |
| SMR | Q8D8C7 | 555-610.1 | |
| GenomeReviews | AE016795_GR | VV13053.1 | |
| BioCyc | VVUL216895:VV13053-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMCP6;
RA Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H.,
RA Choy H.E.;
RT "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 610 UvrABC system protein C.
/FTId=PRO_0000138360.
DOMAIN 204 239 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 610
MTQIFDSVSF LKTVTHQPGV YRMYNAEAVV IYVGKAKDLK KRLSSYFRKK VDSEKTKALV
SNIAKIDVTV THTETEALIL EHNYIKQYLP KYNVLLRDDK SYPYIFLSAH RHPRVSLHRG
AKKRKGEYFG PYPDSGAVRE TLHLIQKIFP VRQCEDTVYA NRTRPCLMYQ IGRCAGPCVS
SVISDVDYAE LVGYLRLFLQ GKDNQVLELL VQKMEIASQQ LKFEDAAKFR DQIQAIRRVQ
EQQYVSEDSQ EDMDVLGFAQ ENGIACIHIL MIRQGKVLGS RSHFPKIPQN TNAQEVFDSF
LTQYYLSHNE ARTIPSRIIL NQELAADVEA IQLALSDVAG RKVQFHTSPS GSRGRYLKLS
NTNALTAMTT KINHKMTINQ RFKALRDVLA MDSIARMECF DISHTMGEST IASCVVFNSE
GPVKQEYRRY NITGITGGDD YAAMGQALER RYAKQLDVEK IPDIIFIDGG KGQLNRAHEI
IVQYWGDWPK RPVMIGIAKG VTRKPGLETL ITVDGDEFHL PSDDPALHLI QHIRDESHNH
AIAGHRAKRG KTRKTSALEG IEGVGPKRRQ ALLKYTGGLQ ELKRASVEEI AKVPGISHSL
AEIIYQALKQ