Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 68867
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 17.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Alteromonadales Shewanellaceae Shewanella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_SHEON:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE015629 | AAN54913.1 | - |
| GenomeReviews | AE014299_GR | SO1861.1 | |
| TIGR | SO1861 | -. | |
| BioCyc | SONE211586:SO1861-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 2. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MR-1;
RX MEDLINE=22297686; PubMed=12368813; DOI=10.1038/nbt749;
RA Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C.,
RA Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A.,
RA Clayton R.A., Meyer T., Tsapin A., Scott J., Beanan M.J.,
RA Brinkac L.M., Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S.,
RA Haft D.H., Kolonay J.F., Madupu R., Peterson J.D., Umayam L.A.,
RA White O., Wolf A.M., Vamathevan J.J., Weidman J.F., Impraim M.,
RA Lee K., Berry K.J., Lee C., Mueller J., Khouri H.M., Gill J.,
RA Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O.,
RA Venter J.C., Nealson K.H., Fraser C.M.;
RT "Genome sequence of the dissimilatory metal ion-reducing bacterium
RT Shewanella oneidensis.";
RL Nat. Biotechnol. 20:1118-1123(2002).
Feature:
CHAIN 1 609 UvrABC system protein C.
/FTId=PRO_0000138335.
DOMAIN 203 238 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 609
MSTGFNAQSF LRTVTSSAGV YRMYDVKGDV IYVGKAKDLK KRLSSYFRKN LGNVKTQALV
SHIHHIDVTL THSETDALLL ENDYIKQYMP KYNVLLRDDK SYPYILLSQH EHPRLAYHRG
PQREKGHYFG PYPNGGAVRE SLHLMQKLFP IRQCDDLYYK SRTRPCLQYQ LSRCSAPCVG
KVSNAEYDEQ VKLASLFLKG KDKQVISELV AKMEEAAEQQ AYEQAARFRD QIMALRRVAE
QQEVSGNTGD MDVIGVHYAS GIACFHLLFI REGKIFGSRS YYPTVPAQTD IEEVLRSFLL
QFYLNADIQR TIPKEVVISH HFEELHELEA AVSEALNKKF SIKTNVRADR ASFLRLAITN
ATNAVMTRLS HKNTVEQRFV LLEEILELNA PIQRMECFDI SHTMGESTVA SCVVFNREGP
HKAEYRRYNI EGITPGDDYA AMKQAISRRF DKIDASGKIP DILFIDGGLG QLRIAQQIVD
EKFVNLDKAP QLIGVAKGES RKPGLETLIF GDTETSFSLE DDSPALHLIQ HIRDESHRFA
ITGHRNRRQK TRNTSTLESI PGIGPKRRKA LLQHLGGLQE VKGASVAELA KVPGISIEMA
QTIHDALRG