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Description:
Transcriptional regulator ATRX homolog (EC 3.6.1.-) (ATP-dependenthelicase XNP) (X-linked nuclear protein) (dXNP) (d-xnp).
Molecular weight: 1482
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
02-NOV-2001, sequence version 2.
07-FEB-2006, entry version 38.
Phylogenetic order:
Eukaryota Metazoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein ATRX_DROME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF217802 | AAG40586.1 | - |
| EMBL | AE003752 | AAF56471.1 | - |
| EMBL | AY058592 | AAL13821.1 | - |
| Ensembl | CG4548 | Drosophila melanogaster.1 | |
| FlyBase | FBgn0039338 | XNP. | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-013412-MONOMER | -.1 | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-013413-MONOMER | -.1 | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR000330 | SNF2_N. | |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF00176 | SNF2_N | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nuclear protein; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RA Cardoso C., Usseglio F., Villard L., Manfruelli P., Rothbacher U.,
RA Aragnol D., Pradel J., Fontes M.;
RT "d-xnp: Drosophila melanogaster xnp/atr-x gene.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RX MEDLINE=22426069; PubMed=12537572;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX MEDLINE=22426066; PubMed=12537569;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA Rubin G.M., Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
Feature:
CHAIN 1 1311 Transcriptional regulator ATRX homolog.
/FTId=PRO_0000074309.
NP_BIND 489 496 ATP (Potential).
MOTIF 615 618 DEGH box.
COMPBIAS 69 74 Poly-Ser.
COMPBIAS 162 165 Poly-Glu.
COMPBIAS 301 307 Poly-Glu.
CONFLICT 785 785 N -> T (in Ref. 1).
Comments:
-!- FUNCTION: Could be a global transcriptional regulator. Modifies
gene expression by affecting chromatin (Potential).
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
-!- SIMILARITY: Contains 1 helicase domain.
-!- SIMILARITY: Contains 1 SNF2_N domain.
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Sequence length: 1311
MGKKNPNARH TDAATPLTTD DSNSSSVSRR ESATESKSAS ESESSPPRSN TKQSRTHKNV
KASGKATVSS SSDSDQAVAN SSANDEEKEP VCKIRIVPLE KLLASPKTKE RPSRGSQQKN
VTINDSSDEE PLKGSKLVLP ARKSRNKNAS IIELSDSEEV DEEEESLLVA IPLPKEAQQT
KPEKNSSKAS KESIEKRQKA QKEATTSSAR AIRSVNGTRR GSLSSERSSR ASSSRAESPP
RPKRCVVRLK RVSLPKTKPA QKPKKMSSDS EEAATTSKKS RQRRSKSESE ADSDYEAPAA
EEEEEEERKS SGDEEEAANS SDSEVMPQRK RRRKKSESDK GSSDFEPEEK QKKKGRKRIK
KTSSGESDGD GDDDKQKNKR KHIRKIIKTK DLDLTTKEAA KEEDDRRKRI EDRQKLYNRI
FVKSESVEIN ELVLDFDEES KKALLQVDKG LLKKLKPHQV AGVKFMWDAC FETLKESQEK
PGSGCILAHC MGLGKTLQVV TLSHTLLVNT RRTGVDRVLI ISPLSTVNNW AREFTSWMKF
ANRNDIEVYD ISRYKDKPTR IFKLNEWFNE GGVCILGYDM YRILANEKAK GLRKKQREQL
MQALVDPGPD LVVCDEGHLL KNEKTSISKA VTRMRTKRRI VLTGTPLQNN LREYYCMIQF
VKPNLLGTYK EYMNRFVNPI TNGQYTDSTE RDLRLMKHRS HILHKLLEGC IQRRDYSVLA
PYLPPKHEYV VYTTLSELQQ KLYGYYMTTH REQSGGDVVG KGARLFQDFQ DLRRIWTHPM
NLRVNSDNVI AKRLLSNDDS DMEGFICDET DEDEAASNSS DSCETFKSDA SMSGLAASSG
KVKKRKTRNG NAGGGDSDSD LEMLGGLGGG SSVQKDDPSE WWKPFVEERE LNNVHHSPKL
LILLRLLQQC EAIGDKLLVF SQSLQSLDVI EHFLSLVDSN TKNYEFEGDV GDFKGCWTSG
KDYFRLDGSC SVEQREAMCK QFNNITNLRA RLFLISTRAG GLGINLVAAN RVVIFDVSWN
PSHDTQSIFR VYRFGQIKPC YIYRLIAMGT MEQKVYERQV AKQATAKRVI DEQQISRHYN
QTDLMELYSY ELKPSTEREM PILPKDRLFA EILTEHEKLI FKYHEHDSLL EQEEHENLTE
EERKSAWAEY EAEKTRTVQA SQYMSYDRNA FGNQVMGQFG NASGSVTSNK IFGFRSDILL
QLLNMKISKD HQELNQNQVI QLVPTYLQQL YNEMNNGDPT MYKDLLNLHS NIVHPSGMYM
NPLLYANQNP NAAGYNQGTG GVPPMAGGSV AHGPPAAPAP GFEPDKVYEI D