Description:
Bloom syndrome protein homolog (EC 3.6.1.-) (Dmblm) (Mutagen-sensitiveprotein 309) (RecQ helicase homolog).
Molecular weight: 1660
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair synthesis( GO:0000731 ) double-strand break repair( GO:0006302 ) double-strand break repair via synthesis-dependent strand annealing( GO:0045003 )
Important dates:
02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
07-FEB-2006, entry version 41.
Phylogenetic order:
Eukaryota Metazoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein BLM_DROME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U92536 | AAD41441.1 | - |
| EMBL | AE003692 | AAF54691.1 | - |
| Ensembl | CG6920 | Drosophila melanogaster.1 | |
| FlyBase | FBgn0002906 | mus309. | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-011132-MONOMER | -.1 | |
| GO | GO:0004003 | F:ATP-dependent DNA helicase activity | IDA. |
| GO | GO:0000731 | P:DNA synthesis during DNA repair | IMP. |
| GO | GO:0006302 | P:double-strand break repair | IMP. |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR002464 | DEAH_box. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR002121 | HRDC. | |
| InterPro | IPR004589 | RecQ. | |
| PANTHER | PTHR13710 | RecQ.1 | 1. |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF00570 | HRDC | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00614 | recQ_fam | 1. |
| PROSITE | PS00690 | DEAH_ATP_HELICASE | 1. |
| PROSITE | PS50967 | HRDC | 1. |
Keywords:
ATP-binding; Complete proteome; DNA replication; DNA-binding; Helicase; Hydrolase; Nuclear protein; Nucleotide-binding; Repeat.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE, AND REPEATS.
RC STRAIN=Canton-S;
RX MEDLINE=99160561; PubMed=10049920;
RA Kusano K., Berres M.E., Engels W.R.;
RT "Evolution of the RECQ family of helicases: a Drosophila homolog,
RT Dmblm, is similar to the human Bloom syndrome gene.";
RL Genetics 151:1027-1039(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RX MEDLINE=22426069; PubMed=12537572;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
Feature:
CHAIN 1 1487 Bloom syndrome protein homolog.
/FTId=PRO_0000205044.
REPEAT 89 112 1.
REPEAT 115 138 2.
DOMAIN 1283 1363 HRDC.
NP_BIND 759 766 ATP (By similarity).
REGION 89 138 2 X 24 AA repeats of L-D-L-S-V-S-P-L-A-E-
L-[SP]-A-K-K-K-[YS]-[AD]-R-D-[SP]-P-P-K-
P.
MOTIF 865 868 DEAH box.
MOTIF 1416 1432 Nuclear localization signal (By
similarity).
COMPBIAS 225 230 Poly-Pro.
COMPBIAS 464 467 Poly-Ser.
COMPBIAS 1369 1372 Poly-Glu.
CONFLICT 98 98 K -> E (in Ref. 1).
CONFLICT 110 110 K -> P (in Ref. 1).
CONFLICT 126 126 L -> P (in Ref. 1).
CONFLICT 134 136 SPK -> PPP (in Ref. 1).
CONFLICT 169 169 Q -> P (in Ref. 1).
CONFLICT 222 222 P -> S (in Ref. 1).
CONFLICT 299 299 Y -> N (in Ref. 1).
CONFLICT 417 417 M -> V (in Ref. 1).
CONFLICT 459 459 Q -> R (in Ref. 1).
CONFLICT 471 471 S -> C (in Ref. 1).
CONFLICT 496 496 H -> P (in Ref. 1).
CONFLICT 594 594 D -> G (in Ref. 1).
CONFLICT 614 614 G -> A (in Ref. 1).
CONFLICT 805 805 K -> E (in Ref. 1).
CONFLICT 1116 1116 E -> G (in Ref. 1).
Comments:
-!- FUNCTION: Participates in DNA replication and repair. Exhibits a
magnesium-dependent ATP-dependent DNA-helicase activity that
unwinds single- and double-stranded DNA in a 3'-5' direction (By
similarity).
-!- SUBCELLULAR LOCATION: Nucleus (By similarity).
-!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
-!- SIMILARITY: Contains 1 HRDC domain.
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Sequence length: 1487
MSKKPVAQRK QLTLSSFIGL DGNSQSQPKS RAASVRSKPP AVYNPIFLDA SSSDDETTEI
SSQSNNGTIA TKKSSRDPRT AKLKKHTYLD LSVSPLAKLS AKKYARDSPK KPTSLDLSVS
PLAELLAKKS DRDSPKKPVQ NENSYTYRGL SESPVENKSI GDTLRKPPQK ERKTSIVWLS
DSPEKKVTQN ERKILDSPLQ RFSFEDFPNK ENGNRHHLLT LPDSPPPPQP VKKPEKTMWQ
NETKTIQDKD SPANPLVSNN LASISTLLDS SRAPNTYKGS SRNLFEDSPE KSGSGEQGYK
LGSAKENEIP TKPATASLER NSVTSSPSPA APLKPRYSVA FDNSLADYLK DLAQNDNFSI
DPNKQNTETL KSTLGFFRNT YVELMEKYCS LIDQIPAMHF NEIAGFQPNT FLKLKVMRQK
FKARTQLVQN SLDKKESQLK AEQEALEKEE IEMQAEQAQQ TVLSSSSPEK SRPIMPLPKV
QEIKDEKIPN RNQLIHDLCG EPDNFSPPSS PRDTQLIPKR QQLINDLCGE PDDFSPPSKQ
NDPHLLRKCE ELVHDLCEEP DDYLAQSMML DGDLEEEQLN GPTQGTTTSG MDDDEDDLEG
LLAEIEDEHQ KMQGRRSEFN GYSYKELEAV KVKEKHKETP INISLDDDGF PEYDEAMFEQ
MHSQAAANKS RVSSAGPSTS KSVVPTKQTS ALHSQKLSGN FHANVHNDGI TGEFDGQKFE
HSTRLMHGLS YSFGLKSFRP NQLQVINATL LGNDCFVLMP TGGGKSLCYQ LPAILTEGVT
IVISPLKSLI FDQINKLASL DICAKSLSGE QKMADVMAIY RDLESQPPMV KLLYVTPEKI
SSSARFQDTL DTLNSNNYIS RFVIDEAHCV SQWGHDFRPD YKKLGVLKKR FPNVPTIALT
ATATPRVRLD ILAQLNLKNC KWFLSSFNRS NLRYRVLPKK GVSTLDDISR YIRSKPQHFS
GIIYCLSRKE CDETSKKMCK DGVRAVSYHA GLTDTDRESR QKDWLTGKMR VICATVAFGM
GIDKPDVRFV LHYSLPKSIE GYYQEAGRAG RDGDVADCIL YYNYSDMLRI KKMLDSDKAL
QYNVKKIHVD NLYRIVGYCE NLTDCRRAQQ LDYFGEHFTS EQCLENRETA CDNCINKRAY
KAVDALEHAR KAARAVKDLC SGRSRFTLLH IADVLKGSKI KKIIDFNHHK TPHHGVLKDW
DKNDVHRLLR KMVIDGFLRE DLIFTNDFPQ AYLYLGNNIS KLMEGTPNFE FAVTKNAKEA
KAAVGSVSDG ATSSTADGQS GMREIHERCY TDLLDLCRTI ASQRNVTMAS IMNIQALKSM
AETLPITEKD MCSIPHVTKA NFDKYGAKLL EITSNYASEK LLMQAVLDEE EEQAAAKQRP
STSGWNNESV DWDMAVASQG NANTSGASGF NSFRAGKRKK IYKSGASKRY KTSTTSPAAR
KTTSARGRGG RAGAKRAESS ASSASGWKSK KTGNSFGFDL MPLPGSK