|
|
|
|
|
|
Description:
Protein mei-9 (Protein meiotic 9).
Molecular weight: 10951
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 ) mismatch repair( GO:0006298 ) double-strand break repair( GO:0006302 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
30-AUG-2005, sequence version 2.
07-MAR-2006, entry version 34.
Phylogenetic order:
Eukaryota Metazoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MEI9_DROME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U27181 | AAC46917.1 | ALT_FRAME |
| EMBL | AE003430 | AAF45938.1 | - |
| EMBL | BT001319 | AAN71074.1 | - |
| PIR | S58936 | S58936. | |
| HSSP | Q8TZH8 | 1J24 | |
| Ensembl | CG3697 | Drosophila melanogaster.1 | |
| FlyBase | FBgn0002707 | mei-9. | |
| GO | GO:0005515 | F:protein binding | IPI. |
| GO | GO:0006302 | P:double-strand break repair | TAS. |
| GO | GO:0045132 | P:meiotic chromosome segregation | IMP. |
| GO | GO:0006298 | P:mismatch repair | IMP. |
| GO | GO:0006289 | P:nucleotide-excision repair | IMP. |
| GO | GO:0000712 | P:resolution of meiotic joint molecules as re... | TAS. |
| InterPro | IPR006166 | ERCC4. | |
| InterPro | IPR006167 | Rad1. | |
| Pfam | PF02732 | ERCC4 | 1. |
| TIGRFAMs | TIGR00596 | rad1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; DNA-binding; Endonuclease; Hydrolase; Meiosis; Nuclear protein; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=96109608; PubMed=8647398;
RA Sekelsky J.J., McKim K.S., Chin G.M., Hawley R.S.;
RT "The Drosophila meiotic recombination gene mei-9 encodes a homologue
RT of the yeast excision repair protein Rad1.";
RL Genetics 141:619-627(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RX MEDLINE=22426069; PubMed=12537572;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RX MEDLINE=22426066; PubMed=12537569;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA Rubin G.M., Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
Feature:
CHAIN 1 961 Protein mei-9.
/FTId=PRO_0000198855.
CONFLICT 115 115 V -> G (in Ref. 1).
CONFLICT 286 286 S -> T (in Ref. 1 and 4).
CONFLICT 318 318 S -> T (in Ref. 1).
CONFLICT 594 594 A -> P (in Ref. 1).
CONFLICT 798 798 A -> R (in Ref. 1).
CONFLICT 853 853 T -> M (in Ref. 1 and 4).
Comments:
-!- FUNCTION: Implicated in recombination events during meiosis,
mostly in meiotic exchange. May directly resolve Holliday
junctions within recombination intermediates leading to DNA
exchange. Also required for the repair of mismatches within
meiotic heteroduplex DNA and for nucleotide excision repair.
-!- SUBUNIT: Heterodimer (By similarity).
-!- SUBCELLULAR LOCATION: Nucleus (Probable).
-!- SIMILARITY: Belongs to the XPF family.
-!- CAUTION: Ref.1 sequence differs from that shown due to several
frameshifts.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 961
MADSCAENAA KGTENERPKE VEASADTVPQ VEEGVEEYLK RKNMVLLDYE KQMFLDLVEA
DGLLVCAKGL SYDRVVISIL KAYSDSGNLV LVINSSDWEE QYYKSKIEPK YVHEVASTAT
ERERVYLEGG LQFISTRILV VDLLKQRIPI ELISGIIVLR AHTIIESCQE AFALRLFRQK
NKTGFVKAFS SSPEAFTIGY SHVERTMRNL FVKHLYIWPR FHESVRTVLQ PWKIQSIEMH
VPISQNITSI QSHILEIMNF LVQEIKRINR TVDMEAVTVE NCVTKSFHKI LQAQLDCIWH
QLNSQTKLIV ADLKILRSLM ISTMYHDAVS AYAFMKRYRS TEYALSNSGW TLLDAAEQIF
KLSRQRVFNG QQEFEPEPCP KWQTLTDLLT KEIPGDMRRS RRSEQQPKVL ILCQDARTCH
QLKQYLTQGG PRFLLQQALQ HEVPVGKLSD NYAKESQTRS APPKNVSSNK ELRREEVSGS
QPPLAGMDEL AQLLSESETE GQHFEESYML TMTQPVEVGP AAIDIKPDPD VSIFETIPEL
EQFDVTAALA SVPHQPYICL QTFKTEREGS MALEHMLEQL QPHYVVMYNM NVTAIRQLEV
FEARRRLPPA DRMKVYFLIH ARTVEEQAYL TSLRREKAAF EFIIDTKSKM VIPKYQDGKT
DEAFLLLKTY DDEPTDENAK SRQAGGQAPQ ATKETPKVIV DMREFRSDLP CLIHKRGLEV
LPLTITIGDY ILTPDICVER KSISDLIGSL NSGRLYNQCV QMQRHYAKPI LLIEFDQNKP
FHLQGKFMLS QQTSMANADI VQKLQLLTLH FPKLRLIWSP SPYATAQLFE ELKLGKPEPD
PQTAAALGSD EPTAGEQLHF NSGIYDFLLR LPGVHTRNIH GLLRKGGSLR QLLLRSQKEL
EELLQSQESA KLLYDILHVA HLPEKDEVTG STALLAASKQ FGAGSHNRFR MAAAASRRGR
R