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Description:
Probable DNA mismatch repair protein MSH6.
Molecular weight: 1331
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
21-FEB-2001, sequence version 2.
07-FEB-2006, entry version 34.
Phylogenetic order:
Eukaryota Metazoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MSH6_DROME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE003532 | AAF49656.2.1 | - |
| HSSP | P23909 | 1OH6 | |
| Ensembl | CG7003 | Drosophila melanogaster.1 | |
| FlyBase | FBgn0036486 | CG7003. | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-016742-MONOMER | -.1 | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RX MEDLINE=22426069; PubMed=12537572;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
Feature:
CHAIN 1 1190 Probable DNA mismatch repair protein
MSH6.
/FTId=PRO_0000115209.
NP_BIND 958 965 ATP (Potential).
Comments:
-!- FUNCTION: Involved in post-replicative DNA-mismatch repair (By
similarity).
-!- SUBUNIT: Heterodimer of Msh2/Spel and Msh6 (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 1190
MSKKLNTSVG GTPTNTLLNY FSKSPAFDKK KLTPSVKTDP DASKSEKENL QNQQPKVKDG
KKEASKPAAK RKLPISDDEP ASGQRKRKRI VQPESDSEPE MEVTKSEDDF SDCASDYEPD
ENEASDDSVS SGAEEVSPSE NDMSVDSPTP KKSRKKSKIL NNNNNNEPSS KKVKLESTIQ
LAEGATFQEK LKNLQSNAKQ DASYDDIVTN TSNLDEPVVW PHQKLEFLQP DKIKDKEGRR
PDHPDYDKST LHVPEKFLNG LSPGVRQWWV LKSDNYDCVL FFKVGKFYEL YHMDADVGVN
ELGFTYMRGE FAHSGFPEIS FDKMSTILVD RGFKVARVEQ TETPDMMTER CKRIKATKFD
KVVAREICQI TNRGTQVFGS QCKIGPNHQP NYMLAIVEKD EGTCSRYGVC FIDTSIGDFH
LGEFEDDKNC SRLLTLVSHH MPVLFLNEKS ALSQRTQQIV RTVLGGILKE PVPGNGKHAC
SAEKTLKLLA ERYYAGPGSD DNWPLVLRTM QSDMDHLGLT PNDNYKLALK ALGQCIFFIH
KCKLEPKVLP MARYQLYVPP DQLADAKPAV ASTLRRSHMV LDATTLSNLR IIGEEHSLLS
TLDHCCTKFG KRLLHHWLCA PSCDVSVIKE RQDAIGELIR MPTELQEVRA LLAPMPDFER
NLAQIHLFGN KQIKQMDHPD SRAILFEEKL YNKQKLQGFM AVLKGFNDLT KLPTMFHQCK
TTLLKRITQL PESGGSFPDL SKELQYFATA FDHDAAAKTG VIAPQAGMDA EYDAAMDSIG
EVEKRLKTYL VEQERHFGCR ITYFGSDKKR YQLDVPESHA SKANKSYTLE GQTKGKKPSR
RYTTAETRAL LKDMQHAEDT RNMVLKDLAR RLFEKFSNHY DQWKQCIDCV ANLDVLGSLA
EYAGQQMVIC VPELVSDADQ PFIQLEEGYH PCANASTYIP NGLELGTASE APLSLLTGPN
MGGKSTLMRE VGLLVIMAQI GAHIPAASCR LSLVDRIFTR LGAQDDILAG HSTFLVELNE
TSLILKHATC HSLVLLDELG RGTATYDGTA IAASVVNFLA NLKCRTLFST HYHNLIDFFH
NDKRITLGHM ACMVENEDNA DPTQETVTFL YKYTAGACPK SYGFNAAKLA GMPQGIIKRA
YELSKKVEAI ALQRKITAKI VAATAGNEDT KKEKINALKD LLKQLKMCQV