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Description:
40S ribosomal protein S3.
Molecular weight: 27471
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
07-MAR-2006, entry version 55.
Phylogenetic order:
Eukaryota Metazoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RS3_DROME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L13690 | AAA28875.1 | - |
| EMBL | X72921 | CAA51425.1 | - |
| EMBL | AE003743 | AAF56129.1 | - |
| EMBL | AY118971 | AAM50831.1 | - |
| PIR | S35620 | S35620. | |
| SMR | Q06559 | 8-191.1 | |
| IntAct | Q06559 | -.1 | |
| Ensembl | CG6779 | Drosophila melanogaster.1 | |
| FlyBase | FBgn0002622 | RpS3. | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-012978-MONOMER | -.1 | |
| GO | GO:0005515 | F:protein binding | IPI. |
| InterPro | IPR004044 | KH_TYPE_2. | |
| InterPro | IPR005703 | Ribos_S3_euk_arc. | |
| InterPro | IPR001351 | Ribosomal_S3_C. | |
| Pfam | PF07650 | KH_2 | 1. |
| Pfam | PF00189 | Ribosomal_S3_C | 1. |
| TIGRFAMs | TIGR01008 | rpsC_E_A | 1. |
| PROSITE | PS50823 | KH_TYPE_2 | 1. |
| PROSITE | PS00548 | RIBOSOMAL_S3 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclear protein; Nuclease; Ribonucleoprotein; Ribosomal protein.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX MEDLINE=93281407; PubMed=7685082;
RA Wilson D.M. III, Deutsch W.A., Kelley M.R.;
RT "Cloning of the Drosophila ribosomal protein S3: another
RT multifunctional ribosomal protein with AP endonuclease DNA repair
RT activity.";
RL Nucleic Acids Res. 21:2516-2516(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Shahrinau / Wild type;
RX MEDLINE=94350207; PubMed=8070662;
RA Andersson S., Saeboe-Larssen S., Lambertsson A., Meriam J.,
RA Jacobs-Lorena M.;
RT "A Drosophila third chromosome Minute locus encodes a ribosomal
RT protein.";
RL Genetics 137:513-520(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RX MEDLINE=22426069; PubMed=12537572;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX MEDLINE=22426066; PubMed=12537569;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA Rubin G.M., Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP DNA REPAIR ACTIVITY.
RX MEDLINE=96208517; PubMed=8641296;
RA Yacoub A., Augeri L., Kelley M.R., Doetsch P.W., Deutsch W.A.;
RT "A Drosophila ribosomal protein contains 8-oxoguanine and abasic site
RT DNA repair activities.";
RL EMBO J. 15:2306-2312(1996).
Feature:
CHAIN 1 246 40S ribosomal protein S3.
/FTId=PRO_0000130328.
DOMAIN 23 94 KH type-2.
CONFLICT 46 47 SR -> FG (in Ref. 2).
CONFLICT 62 62 G -> A (in Ref. 2).
CONFLICT 114 114 G -> E (in Ref. 2).
Comments:
-!- FUNCTION: Has DNA repair activity directed towards the mutagenic
lesions 8-oxoguanine and absis sites in DNA. It can cleave DNA
containing 8-oxoguanine residues efficiently. Also acts as an ap
lyase, cleaving phosphodiester bonds via a beta,delta elimination
reaction.
-!- INTERACTION:
Q9VK13:CG15479; NbExp=1; IntAct=EBI-114639, EBI-147587;
-!- SUBCELLULAR LOCATION: Nuclear and cytoplasmic.
-!- SIMILARITY: Belongs to the ribosomal protein S3P family.
-!- SIMILARITY: Contains 1 KH type-2 domain.
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Sequence length: 246
MNANLPISKK RKFVSDGIFK AELNEFLTRE LAEDGYSGVE VRVTPSRTEI IIMATKTQQV
LGEKGRRIRE LTAMVQKRFN FETGRIELYA EKVAARGLCA IAQAESLRYK LTGGLAVRRA
CYGVLRYIME SGAKGCEVVV SGKLRGQRAK SMKFVDGLMI HSGDPCNDYV ETATRHVLLR
QGVLGIKVKV MLPYDPKNKI GPKKPLPDNV SVVEPKEEKI YETPETEYKI PPPSKPLDDL
SEAKVL