|
|
|
|
|
|
Description:
DNA-repair protein complementing XP-A cells homolog (Xerodermapigmentosum group A complementing protein homolog).
Molecular weight: 33875
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
02-NOV-2001, sequence version 3.
07-FEB-2006, entry version 47.
Phylogenetic order:
Eukaryota Metazoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein XPA_DROME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | D31893 | BAA06691.1 | - |
| EMBL | D31892 | BAA06690.1 | - |
| EMBL | AE003430 | AAF45917.1 | - |
| EMBL | AL033125 | CAA21834.1 | - |
| PIR | JQ1325 | JQ1325. | |
| HSSP | P23025 | 1XPA | |
| IntAct | P28518 | -.1 | |
| Ensembl | CG6358 | Drosophila melanogaster.1 | |
| FlyBase | FBgn0004832 | Xpac. | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-000542-MONOMER | -.1 | |
| GO | GO:0005634 | C:nucleus | IDA. |
| GO | GO:0005515 | F:protein binding | IPI. |
| GO | GO:0006289 | P:nucleotide-excision repair | IDA. |
| InterPro | IPR000465 | XPA. | |
| PANTHER | PTHR10142 | XPA.1 | 1. |
| Pfam | PF05181 | XPA_C | 1. |
| Pfam | PF01286 | XPA_N | 1. |
| TIGRFAMs | TIGR00598 | rad14 | 1. |
| PROSITE | PS00752 | XPA_1 | 1. |
| PROSITE | PS00753 | XPA_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; DNA-binding; Metal-binding; Nuclear protein; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=92109732; PubMed=1764072;
RA Shimamoto T., Kohno K., Tanaka K., Okada Y.;
RT "Molecular cloning of human XPAC gene homologs from chicken, Xenopus
RT laevis and Drosophila melanogaster.";
RL Biochem. Biophys. Res. Commun. 181:1231-1237(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=95403447; PubMed=7673233; DOI=10.1074/jbc.270.38.22452;
RA Shimamoto T., Tanimura T., Yoneda Y., Kobayakawa Y., Sugasawa K.,
RA Hanaoka F., Oka M., Okada Y., Tanaka K., Kohno K.;
RT "Expression and functional analyses of the Dxpa gene, the Drosophila
RT homolog of the human excision repair gene XPA.";
RL J. Biol. Chem. 270:22452-22459(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RX MEDLINE=22426069; PubMed=12537572;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R;
RX MEDLINE=20196011; PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D.,
RA Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E.,
RA Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D.,
RA Minana B., Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S.,
RA Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B.,
RA Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F.,
RA Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A.,
RA Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
Feature:
CHAIN 1 296 DNA-repair protein complementing XP-A
cells homolog.
/FTId=PRO_0000208652.
ZN_FING 126 150
MOTIF 26 47 Nuclear localization signal (Potential).
CONFLICT 10 10 S -> A (in Ref. 2).
CONFLICT 224 226 QHE -> HEQ (in Ref. 1).
Comments:
-!- FUNCTION: Involved in DNA excision repair. Initiates repair by
binding to damaged sites with various affinities, depending on the
photoproduct and the transcriptional state of the region (By
similarity).
-!- INTERACTION:
Q9Y0X3:Ercc1; NbExp=1; IntAct=EBI-180490, EBI-125429;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Strongly expressed in the central nervous
system and muscles.
-!- DEVELOPMENTAL STAGE: Continuously expressed in all stages of
development.
-!- SIMILARITY: Belongs to the XPA family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 296
MSAEVSTNES APPAEKKSKL TNAQKARIER NQAKAQKLRE AKLVSHPFKE LASNKEGGTH
PEAALSQGSS VIKVQGTKYI DSGGGFLLEQ PVMPTGVGPA GLNKSGEEAP PILDDAIAIP
VQYEECLECG DMFADSYLFN NFGHSVCDKC RDKDERYALI TRTEAKAEYL LKDCDFDKRE
PKLRYISRKN PHNVRWGEMK LYLHLQIHQR ALEVWGSEEE LVRQHEARED KREEGKARKY
NKKMKQLRME VRSSIYTKKT HEVHEHEFGP DTYDEEEDTY THTCITCPYS ETYEKM