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Description:
DNA-repair protein complementing XP-C cells homolog (Xerodermapigmentosum group C-complementing protein homolog) (XPCDM) (Mutagen-sensitive 209 protein).
Molecular weight: 1442
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
30-AUG-2005, sequence version 2.
07-MAR-2006, entry version 35.
Phylogenetic order:
Eukaryota Metazoa Arthropoda Hexapoda Insecta Pterygota Neoptera Endopterygota Diptera Brachycera Muscomorpha Ephydroidea Drosophilidae Drosophila.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein XPC_DROME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | Z28622 | CAA82262.1 | - |
| EMBL | AF209743 | AAF24766.1 | - |
| EMBL | AF209743 | AAF24767.1 | - |
| EMBL | AE003811 | AAF58150.1 | - |
| EMBL | AE003811 | AAM68530.1 | - |
| EMBL | AE003811 | AAM68531.1 | - |
| EMBL | AY070566 | AAL48037.1 | - |
| PIR | S42402 | S42402. | |
| Ensembl | CG8153 | Drosophila melanogaster.1 | |
| FlyBase | FBgn0004698 | mus210. | |
| InterPro | IPR004583 | Rad4. | |
| PANTHER | PTHR12135 | Rad4.1 | 1. |
| Pfam | PF03835 | Rad4 | 1. |
| TIGRFAMs | TIGR00605 | rad4 | 1. |
Keywords:
Alternative splicing; Complete proteome; DNA damage; DNA repair; DNA-binding; Nuclear protein.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=DP CN BW; TISSUE=Embryo;
RX MEDLINE=94173669; PubMed=8127661;
RA Henning K.A., Peterson C., Legerski R., Friedberg E.C.;
RT "Cloning the Drosophila homolog of the Xeroderma pigmentosum
RT complementation group C gene reveals homology between the predicted
RT human and Drosophila polypeptides and that encoded by the yeast RAD4
RT gene.";
RL Nucleic Acids Res. 22:257-261(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
RX MEDLINE=20274058; PubMed=10812334; DOI=10.1016/S0921-8777(99)00075-0;
RA Sekelsky J.J., Hollis K.J., Eimerl A.I., Burtis K.C., Hawley R.S.;
RT "Nucleotide excision repair endonuclease genes in Drosophila
RT melanogaster.";
RL Mutat. Res. 459:219-228(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RX MEDLINE=22426069; PubMed=12537572;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX MEDLINE=22426066; PubMed=12537569;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA Rubin G.M., Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
Feature:
CHAIN 1 1293 DNA-repair protein complementing XP-C
cells homolog.
/FTId=PRO_0000218295.
MOTIF 922 938 Nuclear localization signal (Potential).
MOTIF 1195 1211 Nuclear localization signal (Potential).
MOTIF 1275 1291 Nuclear localization signal (Potential).
COMPBIAS 33 40 Poly-Asp.
COMPBIAS 632 637 Poly-Ser.
COMPBIAS 686 693 Poly-Ser.
VARSPLIC 1 782 Missing (in isoform 2).
/FTId=VSP_015197.
VARSPLIC 63 63 G -> GS (in isoform 3).
/FTId=VSP_015198.
CONFLICT 109 109 K -> Q (in Ref. 1 and 2).
CONFLICT 134 134 G -> D (in Ref. 1).
CONFLICT 618 618 Y -> H (in Ref. 1).
CONFLICT 743 743 P -> S (in Ref. 1).
CONFLICT 844 844 D -> A (in Ref. 1).
CONFLICT 945 945 D -> E (in Ref. 2).
CONFLICT 1245 1245 E -> D (in Ref. 1).
Comments:
-!- FUNCTION: Involved in DNA excision repair. May play a part in DNA
damage recognition and/or in altering chromatin structure to allow
access by damage-processing enzymes (By similarity).
-!- FUNCTION: Involved in nucleotide excision repair of DNA damaged
with UV light, bulky adducts, or cross-linking agents.
-!- SUBUNIT: Heterodimer (By similarity).
-!- SUBCELLULAR LOCATION: Nucleus (Probable).
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1; Synonyms=A;
IsoId=Q24595-1; Sequence=Displayed;
Name=2; Synonyms=B;
IsoId=Q24595-2; Sequence=VSP_015197;
Name=3; Synonyms=C;
IsoId=Q24595-3; Sequence=VSP_015198;
Note=No experimental confirmation available;
-!- SIMILARITY: Belongs to the XPC family.
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Sequence length: 1293
MSDEEEDSVS EGFSASEDEW KPSKDVKGGE SSDDDDSDFD ELQAEGGAAG SSGRSSAVAG
KRGDHKAPSG IKGSSVKKRK PTGQSLRSKL YNKYRPPPKT FPTSPSQQKE NTPRASGSKN
AKTPNESGAR NQHGPADSSS ESSVEDYLVN PADLDLHSTF FAGGQKEKSP APQFDCNAGI
TNLSDSGSED NNESSFEDKA GNAFDFRGLL ENANSLERTR DALSKRNVTA TPPRSQAATM
DVNALLALGE NQNYQSVEVE EREGNQRKKA GRGAPAAPPT LDEPSRLSKT KSTRIKRHTK
TRPVSTVVAN AGDTDDSDFE EVADADLSSD QDDGETPNIS GDLEIRVGLE GLRPTKEQKT
QHELEMALKR RLNRDIKDRQ ILLHKVSLMC QIARSLKYNR LLSESDSLMQ ATLKLLPSRN
AYPTERGTEL KYLQSFVTWF KTSIKLLSPN LYSAQSPATK EAILEALLEQ VKRKEARCKQ
DMIFIFIALA RGMGMHCRLI VNLQPMPLRP AASDLIPIKL RPDDKNKSQT VESERESEDE
KPKKDKKAGK PAEKESSKST ISKEAEKKNN AKKAEAKPLS KSTTKGSETT KSGTVPKVKK
ELSLSSKLVE KSKHQKAYTS SKSDTSFDEK PSTSSSSKCL KEEYSELGLS KKLLKPTLSS
KLVLKSKNQS SFSSNKSDTS FEENPSTSSS SKSLKEETAK LSSSKLEDKK VASPAETKTK
VQSSLLKRVT TQNISESGDS KKPKVAPVDT FSPVAGRTRR ATVKPKTEEK PQVVGSPVIP
KLMLSKVKQL NAKHSDTENA SPANKHLQEQ RNTRETRSRS KSPKVLISPS FLKKKSDGAD
STSDPQKHQM APETKARISP NFLSEALPAR QLRSRGQKAS SLAIPQLDGG DDVPLPKKRP
KLEKLKNSQD SDEVFEPAKP VKKAPVLPKS VQNLRKDRRV MSTDDEGGSR LNRKTDASDM
WVEVWSDVEE QWICIDLFKG KLHCVDTIRK NATPGLAYVF AFQDDQSLKD VTARYCASWS
TTVRKARVEK AWLDETIAPY LGRRTKRDIT EDDQLRRIHS DKPLPKSISE FKDHPLYVLE
RHLLKFQGLY PPDAPTLGFI RGEAVYSRDC VHLLHSREIW LKSARVVKLG EQPYKVVKAR
PKWDRLTRTV IKDQPLEIFG YWQTQEYEPP TAENGIVPRN AYGNVELFKD CMLPKKTVHL
RLPGLMRICK KLNIDCANAV VGFDFHQGAC HPMYDGFIVC EEFREVVTAA WEEDQQVQVL
KEQEKYETRV YGNWKKLIKG LLIRERLKKK YNF