Description:
Exodeoxyribonuclease I (EC 3.1.11.1) (Exonuclease I) (DNAdeoxyribophosphodiesterase) (dRPase).
Molecular weight: 54388
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
07-MAR-2006, entry version 38.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Haemophilus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein EX1_HAEIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L42023 | AAC23023.1 | - |
| PIR | E64120 | E64120. | |
| HSSP | P04995 | 1FXX | |
| GenomeReviews | L42023_GR | HI1377.1 | |
| TIGR | HI1377 | -. | |
| BioCyc | HINF71421:HI1377-MONOMER | -.1 | |
| InterPro | IPR006055 | Exonuclease. | |
| InterPro | IPR012337 | RNaseH_fold. | |
| Pfam | PF00929 | Exonuc_X-T | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Exonuclease; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rd / KW20 / ATCC 51907;
RX MEDLINE=95350630; PubMed=7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
Feature:
CHAIN 1 473 Exodeoxyribonuclease I.
/FTId=PRO_0000087111.
Comments:
-!- FUNCTION: Also functions as a DNA deoxyribophosphodiesterase that
release deoxyribose-phosphate moieties following the cleavage DNA
at an apurinic/apyrimidinic (AP) site by either an AP endonuclease
AP lyase (By similarity).
-!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in the 3'- to 5'-
direction to yield nucleoside 5'-phosphates.
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Sequence length: 473
MVKDFSFFIY DYESFGVNPA TDRPAQFAGI RTDADFNIIG EPIMFYCKQT NDYLPAPEAV
MVTGITPQEC NEKGLSEPEF AANILAEFSQ PNTCVMGYNN IRYDDEMTRY TFYRNFIEPY
EYSWKNGNSR WDLLDLVRAC YALRPEGINW AYDDDGMPSF RLEKLTKANS IEHENAHDAM
ADVYATIAMA KLIKEKQPKL FQYFFENRGK KEIEKLVDTG AMTPLVHVSG MLGNYRGNCT
WVAPLAWHPT NQNALIVCDL TGDIDNLLAK SADELRADLY TKKLELEERG VSSVPLKLVH
INKCPILAPA KTLLPETANR LGIDRQLCLD NLAKLRASFD IREKVADIFN EERQFASNDN
VETELYNGFF SNADKNNMAI LRSLPAEKLS EHGLAFEDKR ILELLFHYRA RHFYKTLTRA
EQIKWKKYRQ NKLEKSAVEF EASLQRLVEX HSDNSEKLSL LQQVYEYGIK LLG