Description:
Transcription-repair coupling factor (EC 3.6.1.-) (TRCF) (ATP-dependent helicase mfd).
Molecular weight: 1301
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
07-MAR-2006, entry version 44.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Haemophilus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MFD_HAEIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L42023 | AAC22905.1 | - |
| PIR | I64112 | I64112. | |
| HSSP | Q9WY48 | 1GM5 | |
| GenomeReviews | L42023_GR | HI1258.1 | |
| TIGR | HI1258 | -. | |
| BioCyc | HINF71421:HI1258-MONOMER | -.1 | |
| InterPro | IPR003711 | CarD_TRCF. | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004576 | Mfd. | |
| InterPro | IPR005118 | TRCF. | |
| Pfam | PF02559 | CarD_TRCF | 1. |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF03461 | TRCF | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00580 | mfd | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rd / KW20 / ATCC 51907;
RX MEDLINE=95350630; PubMed=7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
Feature:
CHAIN 1 1146 Transcription-repair coupling factor.
/FTId=PRO_0000102167.
DOMAIN 600 970 Helicase.
NP_BIND 630 637 ATP (Potential).
MOTIF 731 734 DEEH box.
Comments:
-!- FUNCTION: Necessary for strand-specific repair. A lesion in the
template strand blocks the RNA polymerase complex (RNAP). The
RNAP-DNA-RNA complex is specifically recognized by TRCF which
releases RNAP and the truncated transcript; the TCRF may replace
RNAP at the lesion site and then recruit the uvrA/B/C repair
system (By similarity).
-!- SIMILARITY: In the N-terminal section; belongs to the uvrB family.
-!- SIMILARITY: In the C-terminal section; belongs to the helicase
family. RecG subfamily.
-!- SIMILARITY: Contains 1 helicase domain.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 1146
MKTAFFQPDI PTQPNDHKIL GNVLPGADAL AISEISEQNQ NLTVVVTPDT RSAVRLSRVL
SELSSQDVCL FPDWETLPYD TFSPHQEIIS SRLSALFHLQ NAKKGIFLLP ISTLMQRLCP
PQYLQHNVLL IKKGDRLVID KMRLQLEAAG YRAVEQVLEH GEYAVRGALL DLFPMGSAVP
FRLDFFDDEI DSIRTFDVDT QRTLDEISSI NLLPAHEFPT DDKGIEFFRA QFRETFGEIR
RDPEHIYQQI SKGTLISGIE YWQPLFFAEM ATLFDYLPEQ TLFVDMENNQ TQGERFYQDA
KQRYEQRKVD PMRPLLSPEK LWLNVDEVNR RLKSYPRITF KAEKVRSSVR QKNLPVAALP
EVTIQSQQKE PLGQLRQFIE HFKGNVLFSV ETEGRRETLL DLLSPLKLKP KQIQSLEQIE
NEKFSLLVSS LEQGFIIEQS LPVAIIGEAN LLGKRIQQRS RDKRKTINPD TLVRNLAELK
IGQPVVHLDH GVGRYGGLVT LDTGGIKAEY LLLNYANESK LYVPVTSLHL ISRYVGGSDE
SAPLHKLGNE AWAKSRQKAA EKIRDVAAEL LDVYAQREAK KGFAFKYDRE EFQQFSATFP
FEETYDQEMA INAVISDMCQ PKAMDRLVCG DVGFGKTEVA MRAAFLAVMN HKQVAVLVPT
TLLAQQHYEN FKDRFANLPV NVEVLSRFKT AKEQKQILEN LAEGKVDILI GTHKLIQSDV
KFNDLGLLII DEEHRFGVGQ KEKIKQLRAN IDILTLTATP IPRTLNMAMN GIRDLSIIST
PPARRLSIKT FVRQNDDLVV REAILREILR GGQVYYLHND VASIENTAEK LTALVPEARV
IVGHGQMRER ELERVMSDFY HQRYNVLVCS TIIETGIDVP TANTIIIERA DHFGLAQLHQ
LRGRVGRSHH QAYAYLLTPP PKMMTKDAER RLDALENLDN LGAGFILATH DLEIRGAGEL
LGNEQSGQIE SIGFSLYMEL LDAAVKALKE GREPSLEELT QQQADIELRV PALLPDDYLG
DVNMRLSFYK RIAAAESKAE LDELKVELID RFGLLPDATK NLLQITELRL LVEPLNVVRI
DAGTQGGFIE FSAKAQVNPD KFIQLIQKEP IVYRFDGPFK FKFMKDLSDN KVRLEFVVDL
LRTIAA