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Description:
DNA mismatch repair protein mutH (Methyl-directed mismatch repairprotein).
Molecular weight: 24906
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
07-MAR-2006, entry version 32.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Haemophilus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTH_HAEIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L42023 | AAC22062.1 | - |
| PIR | H64065 | H64065. | |
| PDB | 2AOQ | X-ray | A=1-223. |
| PDB | 2AOR | X-ray | A/B=1-223. |
| GenomeReviews | L42023_GR | HI0403.1 | |
| TIGR | HI0403 | -. | |
| BioCyc | HINF71421:HI0403-MONOMER | -.1 | |
| HAMAP | MF_00759 | - | 1. |
| InterPro | IPR004230 | MutH. | |
| Pfam | PF02976 | MutH | 1. |
| TIGRFAMs | TIGR02248 | mutH_TIGR | 1. |
Keywords:
3D-structure; Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rd / KW20 / ATCC 51907;
RX MEDLINE=95350630; PubMed=7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
Feature:
CHAIN 1 223 DNA mismatch repair protein mutH.
/FTId=PRO_0000198669.
STRAND 4 5
HELIX 6 16
TURN 17 18
STRAND 20 20
HELIX 21 27
TURN 28 29
STRAND 34 34
STRAND 36 36
TURN 37 38
TURN 40 41
HELIX 42 51
TURN 52 52
TURN 55 56
STRAND 59 61
TURN 62 62
STRAND 63 63
TURN 64 67
STRAND 68 75
TURN 77 78
STRAND 79 79
STRAND 81 83
STRAND 85 89
STRAND 93 94
TURN 96 97
STRAND 100 100
TURN 101 102
HELIX 104 109
STRAND 110 118
TURN 121 122
STRAND 123 123
HELIX 125 127
STRAND 129 130
STRAND 134 136
HELIX 140 158
TURN 159 160
HELIX 162 164
TURN 167 168
STRAND 171 177
STRAND 179 181
TURN 182 183
STRAND 186 189
TURN 191 192
STRAND 193 193
STRAND 195 198
STRAND 201 205
HELIX 207 218
TURN 219 219
Comments:
-!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated
GATC sequences. It is involved in DNA mismatch repair (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the mutH family.
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Sequence length: 223
MIPQTLEQLL SQAQSIAGLT FGELADELHI PVPIDLKRDK GWVGMLLERA LGATAGSKAE
QDFSHLGVEL KTLPINAEGY PLETTFVSLA PLVQNSGVKW ENSHVRHKLS CVLWMPIEGS
RHIPLRERHI GAPIFWKPTA EQERQLKQDW EELMDLIVLG KLDQITARIG EVMQLRPKGA
NSRAVTKGIG KNGEIIDTLP LGFYLRKEFT AQILNAFLET KSL