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Description:
DNA mismatch repair protein mutS.
Molecular weight: 96339
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
07-MAR-2006, entry version 43.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Haemophilus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_HAEIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L42023 | AAC22364.1 | - |
| EMBL | AF003252 | AAB96581.1 | - |
| PIR | G64087 | G64087. | |
| HSSP | P23909 | 1NG9 | |
| SMR | P44834 | 5-802.1 | |
| GenomeReviews | L42023_GR | HI0707.1 | |
| TIGR | HI0707 | -. | |
| BioCyc | HINF71421:HI0707-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rd / KW20 / ATCC 51907;
RX MEDLINE=95350630; PubMed=7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-62.
RC STRAIN=Eagan / Serotype B;
RX MEDLINE=98083063; PubMed=9422600;
RA Martin K., Morlin G., Smith A., Nordyke A., Eisenstark A., Golomb M.;
RT "The tryptophanase gene cluster of Haemophilus influenzae type b:
RT evidence for horizontal gene transfer.";
RL J. Bacteriol. 180:107-118(1998).
Feature:
CHAIN 1 861 DNA mismatch repair protein mutS.
/FTId=PRO_0000115102.
NP_BIND 616 623 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 861
MISEENFQQH TPMMQQYLKL KAENPDILLF YRMGDFYELF YDDAKKAAAL LDISLTKRGQ
SAGQPIPMAG MPYHAVEGYL AKLVQLGESV AICEQIGDPT TSKGPVERQI VRIVTPGTVS
DEALLPERQD NLIAAVYQEK EKFGLATLDM TSGRFQLCEP ADKETLRAEL QRIAPVELLY
CEEFNEMAAI EHCKGLRRRP IWEFELSTAI TLLNRQFGTK DLRAFGVEKS PLGLSAAGCL
LQYAKETQRT ALPHIQSISL IQNQDCIQLD AATRRNLELT QNLAGGTENT LASVLDKCVT
PMGSRLLKRW IHQPVRDVEK LKQRQQSIAE ILNFDLVDEL QPYLQLVGDM ERILARVALR
SARPRDLTRL RTALEQIPAL RAIVQQKTPP FLTALFSQIA DFSEQCDLLQ RALIETPPLL
IRDGGVIAEG YNAELDEWRM LSDGATQYLE NLEKREREST GIDTLKIGFN AVHGYYIQIS
QGQAHKAPIH YVRRQTLKNA ERYIIPELKE YEDKVLKSKG AALALEKQLY DELFDLLLPH
LGSLQLASLA LSELDVLVNL AERADTLNYV MPTFCDEVSV KIKNGRHPVV EQVLKDPFIA
NPVELNHNRH LLVITGPNMG GKSTYMRQTA LITLLAYIGS FVPADSARIG PIDRIFTRIG
ASDDLASGRS TFMVEMTEMA NILHQATAQS LVLIDEIGRG TSTYDGLSLA WACAEWLSKK
IRSLTLFATH YFELTALPEQ LEGIANIHLD ALEHNNTIAF MHAVQNGAAS KSYGLAVAAL
AGVPQSVIKL AKQKLTQLEK NSSYSAEQQI QALREANHNQ GELFFEQETD ALREAIEKLD
PDDLSPKQAL AYLYQLKKMV G