Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 24906
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
27-APR-2001, sequence version 1.
07-MAR-2006, entry version 32.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Pasteurella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_PASMU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006042 | AAK02149.1 | - |
| HSSP | P12295 | 1EUG | |
| GenomeReviews | AE004439_GR | PM0065.1 | |
| BioCyc | PMUL747:PM0065-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pm70;
RX MEDLINE=21145866; PubMed=11248100; DOI=10.1073/pnas.051634598;
RA May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT "Complete genomic sequence of Pasteurella multocida Pm70.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
Feature:
CHAIN 1 222 Uracil-DNA glycosylase.
/FTId=PRO_0000176124.
ACT_SITE 61 61 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 222
MKTWKDVIGT EKTQPYFKHI LDQVHQARAS GKIVYPPPQE VFSAFQLTEF EAVKVVIIGQ
DPYHGPNQAH GLAFSVKPGV VPPPSLMNMY KELTQDIEGF QIPNHGYLVP WAEQGVLLLN
TVLTVEQGKA HSHASFGWET FTDRVIAALN AQREKLVFLL WGSHAQKKGQ FIDRQKHCVF
TAPHPSPLSA HRGFLGCRHF SKTNAYLMAQ GLSPIQWQLA SL