Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 69338
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
27-APR-2001, sequence version 1.
07-MAR-2006, entry version 33.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Pasteurella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_PASMU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006124 | AAK02941.1 | - |
| HSSP | P07025 | 1QOJ | |
| GenomeReviews | AE004439_GR | PM0857.1 | |
| BioCyc | PMUL747:PM0857-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pm70;
RX MEDLINE=21145866; PubMed=11248100; DOI=10.1073/pnas.051634598;
RA May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT "Complete genomic sequence of Pasteurella multocida Pm70.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
Feature:
CHAIN 1 611 UvrABC system protein C.
/FTId=PRO_0000138325.
DOMAIN 204 239 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 611
MLFMFDAKSF LANVSHDAGV YRMYDEKDTV IYVGKAKDLK KRLSSYFRTH LSSKKTEALV
SAIARIDTTI TSSETEALLL EHNYIKTYQP RYNVLLRDDK SYPYILLTAE RHPRISAYRG
SKKIKGEYFG PYPHASAVRE TLSLLQKLFP IRQCENAVYN NRSRPCLQYQ IGRCAAPCVA
GYVTDEAYLQ QVELARLFLQ GKDQQVLEHL IHKMEQASLA LDFEEAARIR DQIQAVRAVM
EKQFVSTERL DDMDILSIAY QLGIACVQVL FIRQGKMLGN RSYFPKVPAN TTLSELTATF
VGQFYLQAHQ GRSIPHRIIV DHKLSEKTEL EELLTQQAGR KVHIQDNTKG EKSKYLQLAK
MNAQSALVTQ LKQSTLLKER YQALQAILQL GEIRRMECFD ISHTMGEQTI ASCVVFNQDG
PLKSDYRRFN ITGITAGDDY AAMEQALLKR YDKPLEQEKI PDVIFIDGGK GQLNRALQTF
SKLNVKWDKN QPHLIGVAKG IDRKAGLETL ILSKQGKILH LPSDHLALHL IQHIRDESHQ
HAISGHRKKR QQAFLQSGLE SVEGVGAKRR QTLLKYLGGM QGVKKATLDE IASVPGISKA
LAERIYDALR D