Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 26391
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
07-MAR-2006, entry version 27.
Phylogenetic order:
Bacteria Fusobacteria Fusobacterales Fusobacteriaceae Fusobacterium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_FUSNN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE009951 | AAL95422.1 | - |
| HSSP | P12295 | 1EUG | |
| GenomeReviews | AE009951_GR | FN1226.1 | |
| BioCyc | FNUC190304:FN1226-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25586;
RX MEDLINE=21886394; PubMed=11889109;
RX DOI=10.1128/JB.184.7.2005-2018.2002;
RA Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L.,
RA Vasieva O., Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A.,
RA Larsen N., D'Souza M., Walunas T., Pusch G., Haselkorn R.,
RA Fonstein M., Kyrpides N.C., Overbeek R.;
RT "Genome sequence and analysis of the oral bacterium Fusobacterium
RT nucleatum strain ATCC 25586.";
RL J. Bacteriol. 184:2005-2018(2002).
Feature:
CHAIN 1 226 Uracil-DNA glycosylase.
/FTId=PRO_0000176097.
ACT_SITE 64 64 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 226
MSKINNDWKE ILEEEFEKEY FIKLKETLEE EYKNYTVYPP KRDILNAFFL TPYSEVKVVL
LGQDPYHQRG QAHGLAFSVN YEIKTPPSLV NMYKELQDDL GLYIPNNGFL EKWSKQGVLL
LNTTLTVRDS EANSHSKIGW QTFTDNVIKS LNEREKPVIF ILWGNNAKSK EKFIDTNKHY
ILKGVHPSPL SANKGFFGCK HFSEANRILK NLGEKEIDWQ IENKEI