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Description:
Aprataxin homolog (Forkhead-associated domain histidine triad-likeprotein) (FHA-HIT).
Molecular weight: 43441
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
07-JUN-2004, sequence version 1.
07-FEB-2006, entry version 16.
Phylogenetic order:
Eukaryota Metazoa Chordata Urochordata Ascidiacea Enterogona Phlebobranchia Cionidae Ciona.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein APTX_CIOIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AY208848 | AAP86338.1 | - |
| Ensembl | ENSCING00000008741 | Ciona intestinalis.1 | |
| InterPro | IPR001310 | HIT. | |
| Pfam | PF01230 | HIT | 1. |
| PROSITE | PS00892 | HIT_1 | 1. |
| PROSITE | PS51084 | HIT_2 | 1. |
| PROSITE | PS00028 | ZINC_FINGER_C2H2_1 | FALSE_NEG. |
| PROSITE | PS50157 | ZINC_FINGER_C2H2_2 | FALSE_NEG. |
Keywords:
DNA damage; DNA repair; Metal-binding; Nuclear protein; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Chen Y., Huang C.-H.;
RT "Identification of human FHA-HIT gene homolog in sea squirt.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 380 Aprataxin homolog.
/FTId=PRO_0000109848.
DOMAIN 36 85 FHA-like.
DOMAIN 206 312 HIT.
ZN_FING 356 378 C2H2-type; atypical.
Comments:
-!- FUNCTION: May be involved in the DNA repair (By similarity).
-!- SUBCELLULAR LOCATION: Nucleus (Probable).
-!- SIMILARITY: Contains 1 C2H2-type zinc finger.
-!- SIMILARITY: Contains 1 FHA-like domain.
-!- SIMILARITY: Contains 1 HIT domain.
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Sequence length: 380
MRILYRLLKM ADDTVKCYLE CCKSSHPKLP LPHNVPVIIG RTPELGITDK LCSRSQLELT
SNCYKRYVLV KRLGANTSQI NGIDIEKNKS SRLEEGQDLH VVNGKFPHRV YFTGCQNDTK
TEKAVVPKLP TKSTDLTKSD LSIKQPERKK LKVSENKSKV LNSKIKPQEK FSSESVYAFD
SPSPMSSRCE KKAESNKRAP THKHWSQGLK ASMEDPELVV KEDEQIVVIK DKYPKAKYHW
LILPKDSISS TKNLSTDNIE LLKHILKVGQ ELAAEVKDKQ PDVEFRFGYH AVASMSQMHM
HVISQDFQSS SFKTKKHWNS FTTDYFVDAT DIINELETGG KVKDRRTMTS LLNEPLKCHR
CKKPQKNIPT LKKHIDSCQK