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Description:
DNA mismatch repair protein mutS.
Molecular weight: 10037
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rickettsiales Rickettsiaceae Rickettsieae Rickettsia spotted fever group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_RICCN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE008604 | AAL02939.1 | - |
| PIR | A97750 | A97750. | |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE006914_GR | RC0401.1 | |
| BioCyc | RCON781:RC0401-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Malish 7;
RX MEDLINE=21442074; PubMed=11557893; DOI=10.1126/science.1061471;
RA Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M.,
RA Raoult D.;
RT "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL Science 293:2093-2098(2001).
Feature:
CHAIN 1 890 DNA mismatch repair protein mutS.
/FTId=PRO_0000115129.
NP_BIND 645 652 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 890
MLLNMNLQEL KQKYNYDVAT KMMQQYLDIK FAHLDCLLLF RMGDFYEMFY EDAILASNVL
GIALTKRGKN GEEEIAMCGV PYHALENYLT KLIEANYKVA ICDQLETPEE AKNRGGYKAV
VTRDVTRIIT PGTIIEENLI ASAEPNYLAS LVIPKNKETA SLCYVDLSTS EIVVVNVPET
EILNELARLK PREILLSENL RSSNLADSIF KQLNFRITYQ VDSFFAINKC EKIILDFYKM
KDIKGIGEIS SSQICAIGSV LEYLSLTQKQ NIPHLPIPRI IKFHSYMTID FSTRRNLEIV
TNSQGGSQGS LLSTLNHTVT KQGGRLLYNF LSSPLTNIAK INHRLNITEF FYSNLEIVKK
IRELLKKTSD IERCLTRITM NRSSGRDLLS IKYTLETATI IKGVFFDAYG FNLPDFIEKI
IKPLSGDAEL YNLIDETIRE DAPNNLNDGG IIKHEYHPKV AQLHDLINNG KLYIEKLKDQ
YRKETGIDSL KISHNNVIGL FIDITAKNVN KILDPKFIHR QTTVNHVRYT TAELQKLESE
LVNAKTLVIS LEKELYADIC SQVIEKASYL RMLASSLSGL DVFCNFAYIA DEYDYVKPEF
TDDLSFDIVK GRHPVVEKAL QRESKSFVYN DCHLSELERI WLITGPNMAG KSTFLRQNAI
IAIIAQIGSF VPAKSAKIGV VDKIFSRIGA ADDLIKGQST FMAEMLETSA ILAQSTKNSL
IILDEVGRGT STYDGVSIAW SVLEYIHDKL KCRCLFATHY HELTVMSNFL PALQNYTIAI
EESGKDILFL HNIISGAADR SYGLHVAALA GLPASVINRA EQILLKFEKT STGKGKNILS
TESNNLSLFY LEPNKTTISS KLDKKFSTID PDKLSPKEAL ELIYELKKLV