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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 38310
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
31-JAN-2002, sequence version 2.
07-MAR-2006, entry version 27.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rickettsiales Rickettsiaceae Rickettsieae Rickettsia spotted fever group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_RICCN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE008615 | AAL03071.1 | ALT_INIT |
| HSSP | Q56313 | 1J7K | |
| GenomeReviews | AE006914_GR | RC0533.1 | |
| BioCyc | RCON781:RC0533-MONOMER | -.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Malish 7;
RX MEDLINE=21442074; PubMed=11557893; DOI=10.1126/science.1061471;
RA Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M.,
RA Raoult D.;
RT "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL Science 293:2093-2098(2001).
Feature:
CHAIN 1 342 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165587.
NP_BIND 57 64 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 342
MTNILSPEKS ENDQELPIRP SYLQEFVGQQ QIKENLSVFI KAAKSRNEHL DHTLFYGPPG
LGKTTLAKII SNEIGGNFKS TSGPAILKVA DLAAILTNLE KNDVLFIDEI HRLNTAVEEV
LYPAMEDFEL DIIIGEGSAA RSVKITLPKF TLIGATTRLG LLSNPLRDRF GIPMRLNFYN
TGELKKVLNR ASKLLDIDLT DSGSEEIAKR SRGTPRIALR LLRRIRDFAA VDGKSRVDKE
ISDFGLNRLE VDRIGLDSND YRYLKFIADN YNGGPVGIET IAAALSEQRD ALEETIEPYL
IQIGLLQRTP RGRVITIAAF EHLKMPVPNQ SHHQFNIFNE NE