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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10631
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
07-MAR-2006, entry version 27.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rickettsiales Rickettsiaceae Rickettsieae Rickettsia spotted fever group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_RICCN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE008676 | AAL03832.1 | - |
| PIR | F97861 | F97861. | |
| HSSP | P58301 | 1F2U | |
| GenomeReviews | AE006914_GR | RC1294.1 | |
| BioCyc | RCON781:RC1294-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| ProDom | PD000006 | ABC_transporter | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 2. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Malish 7;
RX MEDLINE=21442074; PubMed=11557893; DOI=10.1126/science.1061471;
RA Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M.,
RA Raoult D.;
RT "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL Science 293:2093-2098(2001).
Feature:
CHAIN 1 955 UvrABC system protein A.
/FTId=PRO_0000093083.
DOMAIN 347 601 ABC transporter 1.
DOMAIN 612 951 ABC transporter 2.
NP_BIND 35 42 ATP (Potential).
NP_BIND 654 661 ATP (Potential).
ZN_FING 754 780 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 955
MIMNQEYIKV RGAKEHNLKN INVNIPRNKF VVITGLSGSG KSSLAFDTIY AEGQRRYVES
LSSYARQFLH LQNKPNVESI SGLSPAIAID QKTTSKNPRS TVGTITEIYD YLRLLYARVG
IPYSPATGLP IHSQTVSEMV DIINELPKGT KIYLLAPIVR GHKGEFKREI MDLKKQGFQK
LIVNGEVCEI DDLPKLDKNK KHNIEVIVDR IVLDESLGNR LADSLESSLN LAEGITYLEI
VELPPAVKSE FEKNQRITFS EQYSCPVSGF QLTEIEPRIF SFNSPFGACP KCEGIGKEFF
FDRDLIVPDQ RIAIKDGAIV PWGSTASKFI LETLKALADH YKFSIEVPFV SLSQNVKDIL
FEGSGEEAIK FEFHDGSKTQ IIKQPFAGII PSLQEKDRTI ESVLIKEELA KFKSEHKCTA
CSGFRLKDEA LCVKIANLHI GEVAGMSIAA LQKWFSHLEE KLNKKQLFIA ERILKEITER
LKFLMNVGLD YLTLSREAGT LSGGESQRIR LASQIGSGLS GVLYVLDEPS IGLHQRDNTR
LIETLKRLRD LGNTVLVVEH DEETIYEADH IIDIGPGAGI HGGRVIAEGN VEEIKNFEES
ITGRYLSGRQ TIKVPSETRV GHDNRAIELL GAVSNNLDNV DIKIPLGTFT AITGVSGSGK
SSLMIHTLYK AALKHLEPTS KVFPGKYREL KGLEYIDKII DINQSPIGRT PRSNPATYTG
AFTHIRDWFV ELPESKARGY KVGRFSFNVK GGRCEACQGD GLIKIEMHFL PDVYVKCDIC
NGHRYNRETL EIKYKGKSIA DILMMTVEDA MQFFEKIPLI YEKLITLNEV GLGYIKIGQS
ATTLSGGEAQ RVKLAKELSR RSTGKTLYIL DEPTTGLHID DINKLLKVLH KLVDMGNTVL
VIEHNLDVIK TADYIIDVGP EGGDKGGKIV VCGTPADIAA CEESHTGRYL KQYLV