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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 73354
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rickettsiales Rickettsiaceae Rickettsieae Rickettsia spotted fever group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_RICCN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE008641 | AAL03402.1 | - |
| PIR | H97807 | H97807. | |
| GenomeReviews | AE006914_GR | RC0864.1 | |
| BioCyc | RCON781:RC0864-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Malish 7;
RX MEDLINE=21442074; PubMed=11557893; DOI=10.1126/science.1061471;
RA Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M.,
RA Raoult D.;
RT "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL Science 293:2093-2098(2001).
Feature:
CHAIN 1 639 UvrABC system protein C.
/FTId=PRO_0000138331.
DOMAIN 207 242 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 639
MTLEITGSEL IKSKLIDAPE RSGVYRMFDV NKQVLYVGKA KNLKKRLTNY IKSNLDNKTL
RMIANTCFLE YSITNSEVEA LLLEAQLIKK FQPKFNILLK DCKSFPFIKL RLDHDFPQLL
KYRGKTLSDG KFFGPFASSV EVNTTLTELQ KIFKLRSCTD NYFNSRTRPC LQYEIKRCYA
PCVGKINKED YRDLVTQVKD FLQGRTKELQ ENLSRKMEEL SSQMRFEEAA EIRDRIKALS
YVQLKAGVSD VVKDADIIAI VEKNGHYCVE VFLYRAGQAC GNIPYFPTAT ENSTKEEVLE
YFLLQFYQKQ HVPAAIIINH EINDKENVIE AIKKINNILQ INITVPNKGG KAKLVQNAET
HALFSLEQYL KKFAKNQEIM FEIKELFGLS EIPERIEIYD NSHIQGKFAV GVMVVAGKVG
FDKKEYRVFN VHTPSLVCHS RESGDPKRLM DSCFRGNGIK NCGGDIKGDD YEMLRQVLTR
RLTRLRQEPH KLPSLMIIDG GKGHLGVVKE VMDKFEMNIP FVCMSKGVDR NAGFEQFHVI
GKEVFTLDKN LPVMKYLQIL RDEAHNFAIK NHRLGRSRAI KISRLDDIEG VGETRKKALL
HYFGSYKAVC DATIYELAKV NGINKLLAEM IFNVLHRKN