Description:
Transcription-repair coupling factor (EC 3.6.1.-) (TRCF) (ATP-dependent helicase mfd).
Molecular weight: 1276
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
07-MAR-2006, entry version 42.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rickettsiales Rickettsiaceae Rickettsieae Rickettsia typhus group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MFD_RICPR:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AJ235272 | CAA15042.1 | - |
| EMBL | Y11783 | CAA72474.1 | - |
| PIR | H71664 | H71664. | |
| HSSP | Q9WY48 | 1GM5 | |
| GenomeReviews | AJ235269_GR | RP598.1 | |
| BioCyc | RPRO782:RP598-MONOMER | -.1 | |
| InterPro | IPR003711 | CarD_TRCF. | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004576 | Mfd. | |
| InterPro | IPR005118 | TRCF. | |
| Pfam | PF02559 | CarD_TRCF | 1. |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF03461 | TRCF | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00580 | mfd | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Madrid E;
RX MEDLINE=99039499; PubMed=9823893; DOI=10.1038/24094;
RA Andersson S.G.E., Zomorodipour A., Andersson J.O.,
RA Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K.,
RA Eriksson A.-S., Winkler H.H., Kurland C.G.;
RT "The genome sequence of Rickettsia prowazekii and the origin of
RT mitochondria.";
RL Nature 396:133-140(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-1120.
RC STRAIN=Madrid E;
RX MEDLINE=97419517; PubMed=9274032;
RA Andersson J.O., Andersson S.G.E.;
RT "Genomic rearrangements during evolution of the obligate intracellular
RT parasite Rickettsia prowazekii as inferred from an analysis of 52015
RT bp nucleotide sequence.";
RL Microbiology 143:2783-2795(1997).
Feature:
CHAIN 1 1120 Transcription-repair coupling factor.
/FTId=PRO_0000102173.
NP_BIND 604 611 ATP (Potential).
MOTIF 709 712 DEEQ box.
Comments:
-!- FUNCTION: Necessary for strand-specific repair. A lesion in the
template strand blocks the RNA polymerase complex (RNAP). The
RNAP-DNA-RNA complex is specifically recognized by TRCF which
releases RNAP and the truncated transcript; the TCRF may replace
RNAP at the lesion site and then recruit the uvrA/B/C repair
system (By similarity).
-!- SIMILARITY: In the N-terminal section; belongs to the uvrB family.
-!- SIMILARITY: In the C-terminal section; belongs to the helicase
family. RecG subfamily.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 1120
MIQQKFPATA KCFYVIDNFT KNLNQDFILS VSNEEEALQL YKQALFFSSN DNIYYFPSYD
TIPYDHTSPN ANIVSRRAET LTKLITNSKG KLLITHAANL LNKLPPKDFF SKYFLKLYPK
IKFTMDELSM LLVENSFTRN TSSIDVGEFA VRGEIIDIIL PGPKGYRINF SWDYIESIKE
FDINTQISTK YCAELVISPA NEIVLNSETI GNFKNNYLRN FGVNHTDNPL YEAVISGRKF
AGYEQLLPLF YYSCSSLVDY LNNPICIFDN LSKQAILEFE NSYNDFYLAR SKANKLKVNN
FYPTLSPTSL YFTASAITEL LEQKNNILIS YENSEQASLI GNISSISFIE KKTIFDKLFE
IIKANFHKKI IICSSVLSSF ERIKSIIQNY EYTFNEINKL DEAKASVINI GIIPLNQSFY
TKEYLFITSS ELLEEKTLYT NTNKKLKNIL LELDNLKEGE FVVHKDHGIG QFLKLEAFKI
QGKLHDFLKI LYFGNDKLYV PVENIEVIKK YGSDNAELNK LGSVAWNKSK AKLKNRIKEI
SLHLIQIAAK RKLNISTPIE LDLEAYDKFC ANFPFSETED QLTAINDIRE DLTNGMLMDR
LICGDVGFGK TEVAMRAVFM VAKSLNEYLP QVAVVVPTTI LCSQHFSRFI ERFKGFGLNI
KQLSSVISSK EANIIRLELA SGKINIIIGT HALLHKNTKF FNLKLLIIDE EQHFGVSQKE
FLKSLKSSTH VLAMSATPIP RTLQMSMTGL KELSIIATPP LNRLEVRTSV MPFDPVIIRD
ALLREHFRGG RSFYVAPRIK DMEDIEKQLK QIVPELSYKI AHGKMTPSKI DEVMSEFYVG
KFDILISTTI IESGIDIAEA NTMIIHKADT LGLSQLYQLR GRIGRGKIRG YAYLTVASNK
KITSHSLRRL EIIQNSCSLG SGFTIASHDA DLRGFGNLIG EEQSGQIKEV GTELYQEMLE
EQIALLKDDP IVLEQAFIPN INLGLSVFIP DSYVSDSALK IGLYRRIGNL SNEMEVEKFK
DEMIDRFGLL PIEFNNLLDI VKIKLLCFKL NIENLDSGDD GFVIRFYKNA DMTDKILKFV
SRYSNQTKIK PNNKLVFIKK LVDKNIITEV NQLLWTLLEI